Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) with specific molecular pathogenesis and prognosis, which is rare in individuals with acquired immunodeficiency syndrome (AIDS). Due to its rarity and complexity, patients of AIDS complicated with APL usually require individualized and precise treatment strategies. This paper reported a case of AIDS combined wit

Objective  To explore the clinical efficacy and the best course of treatment of cough variant asthma (CVA) in children.Methods  The clinical data of children with CVA who were treated in Children 's Hospital Affiliated to Shandong University from October 2019 to June 2022 were retrospectively analyzed. According to different treatment regimens, they were divided into two groups: inhaled

Objective  To obtain high-yield and high-purity recombinant Irisin protein by recombinant expression and purification in Escherichia coli, and to lay a foundation for the subsequent study of Irisin function.Methods  The CDS sequence of the Irisin gene was codon optimized for gene synthesis, and the recombinant plasmid pET-30a-Irisin was constructed by a one-step cloning and ligation meth

Objective  To construct and apply the virtual simulation training platform for clinical thinking decision in traditional Chinese medicine (TCM), and explore the impact of typical clinical case-based virtual simulation online training on students' clinical thinking ability of TCM, and provide a new approach for digital education in TCM.Methods  The self-constructed virtual simulation trai

Crowned dens syndrome (CDS) is often clinically underestimated due to its lower incidence. CDS is characterized by acute neck pain, cervical stiffness and discomfort, and fever. Laboratory tests showed that C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were markedly elevated. CT is the gold standard for the diagnose of CDS. However, there are few clinical literatures, and there