Phyllodes tumor of the breast (PTB) is a rare fibroepithelial tumor with an incidence of less than 1%, and is common in middle-aged women. PTB may be classified as benign, malignant and borderline according to its histological characteristics, and borderline PTB accounts for 7% to 40%. The tumor size of PTB is generally 4.0 to 7.0 cm, while the giant PTB will be more than 10.0 cm. In this paper, a case of giant borderline PTB exceeding 20 cm with the skin ulceration and cyst within the tumor of the breast was reported,  and its diagnosis and treatment were discussed in conjunction with the literature.

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