Objective  To explore the compatibility rules and application characteristics of Angelicae Sinensis Radix in health food based on data mining, in order to provide reference for the development of its applications.

Methods  Health food containing Angelicae Sinensis Radix were collected, and the information such as dosage forms, distribution of health functions, composition of traditional Chinese medicine, and efficacy categories of health food were counted. VOSviewer 1.6.5 software was used to display the compatibility of ingredients; the Apriori algorithm of IBM SPSS Modeler 18.0 software was applied to mine the compatibility combinations of ingredients, and the Kulc values of each compatibility combination were calculated when taking enhancing immunity and improving nutritional anemia as examples to explore the application rules of Angelicae Sinensis Radix.

Results  A total of 576 health food formulas were included, of which 528 met the requirements and involving 310 types of raw materials, which were used 3 538 times in total. The traditional Chinese medicine compatible with Angelicae Sinensis Radix were mostly tonic, medicines that could promote blood circulation and remove blood stasis, diuretic and dampclearing medicines, and heat-clearing medicines, represented by Astragali Radix, Lycii Fructus, Poria, Ginseng Radix Et Rhizoma, Asini Corii Colla. Health food containing Angelicae Sinensis Radix was mostly capsules and oral liquids, which mainly played a role in enhancing immunity, improving nutritional anemia in clinical application. In terms of enhancing immunity, Angelicae Sinensis Radix was closely related to ingredients such as Astragali Radix, Ginseng Radix Et Rhizoma, Asini Corii Colla, Jujubae Fructus, Rehmanniae Radix Praeparata; and Angelicae Sinensis Radix, Astragali Radix, Asini Corii Colla, Jujubae Fructus, Rehmanniae Radix Praeparata, iron preparations were the key ingredients to improve nutritional anemia.

Conclusion  This study demonstrated the compatibility and application rules of Angelicae Sinensis Radix in health food based on the principles and methods of data mining. The results found that the application of Angelicae Sinensis Radix in health food basically conformed to the theory of traditional Chinese medicine, which could provide reference for the further research.

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