Rare extensive cutaneous metastasis in advanced colorectal cancer: a case report

Published on Dec. 28, 2023Total Views: 1472 times Total Downloads: 695 times Download Mobile

Author: Tao SHI Biao NING Yi-Xin LIU  Yong-Chang WEI

Affiliation: Department of Gastrointestinal Tumors Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Keywords: Colorectal carcinoma Cutaneous metastasis Metastatic tumor

DOI: 10.12173/j.issn.1004-4337.202310084

Reference: Shi T, Ning B, Liu YX, Wei YC. Rare extensive cutaneous metastasis in advanced colorectal cancer: a case report[J]. Journal of Mathematical Medicine, 2023, 36(12): 939-943. DOI: 10.12173/j.issn.1004-4337.202310084[Article in Chinese]  Copied

Abstract
Full-text
References

Abstract

The diagnosis and treatment process of a patient with advanced colon cancer and extensive cutaneous metastasis was retrospectively analyzed in this paper. The incidence, clinical characteristics, and prognosis of this case were summarized, and the advantages of utilizing ⁶⁸Ga-FAPI PET/CT for gastrointestinal tumors were discussed. Cutaneous metastasis in colorectal cancer is rare, characterized by rapid progression, poor prognosis, and diverse clinical manifestations. Therefore, clinicians should remain vigilant in identify skin lesions that may indicate the presence of skin metastasis. Timely diagnosis and intervention are critical to improve patient outcomes.

Full-text

Please download the PDF version to read the full text: download

References

1.Dekker E, Tanis PJ, Vleugels JLA, et al. Colorectal cancer[J]. Lancet, 2019, 394(10207): 1467-1480. DOI: 10.1016/S0140-6736(19)32319-0.

2.Saeed S, Keehn CA, Morgan MB. Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal[J]. J Cutan Pathol, 2004, 31(6): 419-430. DOI: 10.1111/j.0303-6987.2004.00207.x.

3.Alcaraz I, Cerroni L, Rütten A, et al. Cutaneous metastases from internal malignancies: a clinicopathologic and immunohistochemical review[J]. Am J Dermatopathol, 2012, 34(4): 347-393. DOI: 10.1097/DAD.0b013e31823069cf.

4.Gül U, Kiliç A, Gönül M, et al. Spectrum of cutaneous metastases in 1287 cases of internal malignancies: a study from Turkey[J]. Acta Derm Venereol, 2007, 87(2): 160-162. DOI: 10.2340/00015555-0199.

5.Chopra R, Chhabra S, Samra SG, et al. Cutaneous metastases of internal malignancies: a clinicopathologic study[J]. Indian J Dermatol Venereol Leprol, 2010, 76(2): 125-131. DOI: 10.4103/0378-6323.60548.

6.Hu SC, Chen GS, Wu CS, et al. Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center[J]. J Am Acad Dermatol, 2009, 60(3): 379-387. DOI: 10.1016/j.jaad.2008.10.007.

7.Sariya D, Ruth K, Adams-McDonnell R, et al. Clinicopathologic correlation of cutaneous metastases: experience from a cancer center[J]. Arch Dermatol, 2007, 143(5): 613-620. DOI: 10.1001/archderm.143.5.613.

8.Hussein MR. Skin metastasis: a pathologist's perspective[J]. J Cutan Pathol, 2010, 37(9): e1-e20. DOI: 10.1111/j.1600-0560.2009.01469.x.

9.Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients[J]. J Am Acad Dermatol, 1993, 29(2 Pt 1): 228-236. DOI: 10.1016/0190-9622(93)70173-q.

10.Brownstein MH, Helwig EB. Spread of tumors to the skin[J]. Arch Dermatol, 1973, 107(1): 80-86. DOI: 10.1001/archderm.1973.01620160052015.

11.Mehregan AH. Metastatic carcinoma to the skin[J]. Dermatologica, 1961, 123: 311-325. DOI: 10.1159/000255148.

12.Navarro V, Ramón D, Calduch L, et al. Cutaneous metastasis of gastric adenocarcinoma: an unusual clinical presentation[J]. Eur J Dermatol, 2002, 12(1): 85-87. https://pubmed.ncbi.nlm.nih.gov/11809606/.

13.Wong NS, Chang BM, Toh HC, et al. Inflammatory metastatic carcinoma of the colon: a case report and review of the literature[J]. Tumori, 2004, 90(2): 253-255. DOI: 10.1177/030089160409000218.

14.Dehal A, Patel S, Kim S, et al. Cutaneous metastasis of rectal cancer: a case report and literature review[J]. Perm J, 2016, 20(1): 74-78. DOI: 10.7812/TPP/15-078.

15.Kovács KA, Hegedus B, Kenessey I, et al. Tumor type-specific and skin region-selective metastasis of human cancers: another example of the "seed and soil" hypothesis[J]. Cancer Metastasis Rev, 2013, 32(3-4): 493-499. DOI: 10.1007/s10555-013-9418-8.

16.Kauffman CL, Sina B. Metastatic inflammatory carcinoma of the rectum: tumor spread by three routes[J]. Am J Dermatopathol, 1997, 19(5): 528-532. DOI: 10.1097/00000372-199710000-00107.

17.Liu F, Qi L, Liu B, et al. Fibroblast activation protein overexpression and clinical implications in solid tumors: a meta-analysis[J]. PLoS One, 2015, 10(3): e0116683. DOI: 10.1371/journal.pone.0116683.

18.Hamson EJ, Keane FM, Tholen S, et al. Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy[J]. Proteomics Clin Appl, 2014, 8(5-6): 454-463. DOI: 10.1002/prca.201300095.

19.Peng D, He J, Liu H, et al. FAPI PET/CT research progress in digestive system tumours[J]. Dig Liver Dis, 2022, 54(2): 164-169. DOI: 10.1016/j.dld.2021.07.011.

20.Pang Y, Zhao L, Luo Z, et al. Comparison of 68Ga-FAPI and 18F-FDG uptake in gastric, duodenal, and colorectal cancers[J]. Radiology, 2021, 298(2): 393-402. DOI: 10.1148/radiol.2020203275.