Acute pancreatitis (AP) is characterized by rapid progression, large individual differences, and strong insidiousness, which is often accompanied by severe complications such as pancreatic abscess, shock, and multiple organ failure. However, gastric mucosal exfoliation with massive bleeding caused by AP is rare in clinical practice. This article retrospectively analyzed a clinical case of gastric mucosal exfoliation combined with gastrointestinal bleeding induced by severe AP, and discussed the diagnosis, treatment and prognosis of the case, in order to enhance the clinical understanding of rare complications of severe AP, and provide reference for the clinical diagnosis and treatment.

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