Objective  To explore the research status in the field of therapeutic drug monitoring based on bibliometrics, and summarize the research results and hotspots.

Methods Literature related to therapeutic drug monitoring in Web of Science database from 2000 to 2024 was collected. VOSviewer 1.6.20 and CiteSpace 6.4.R1 softwares were applied to conduct the visual analysis through the number of publications, author and institution collaborations, co-cited literature, keywords, etc. The relevant knowledge maps were interpreted.

Results  A total of 3  113 articles were included, the academic attention in this field has shown an overall upward trend in recent years. 901 authors from 565 institutions participated in the research related to therapeutic drug monitoring, and countries such as the USA, the People's Republic of China, Netherlands, Germany, and Italy had a large number of publications. High-frequency keywords prompted the research content in this field mainly involved monitoring populations for therapeutic drugs, evaluation methods, diseases and drugs, and the optimization of clinical medication based on therapeutic drug monitoring has become the current research hotspot.

Conclusion  At present, the research in the field of therapeutic drug monitoring is in a period of rapid development, and its academic attention continues to rise, showing diverse and cross disciplinary characteristics. In recent years, the research hotspots have mainly focused on the patients’ medication optimization based on therapeutic drug monitoring, but collaborations among authors and institutions still need to be strengthened.

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