Objective To explore the clinical efficacy of ginkgo biloba diterpenoid lactone glucosamine combined with urinary kallidinogenase in the treatment of acute cerebral infarction.

Method  84 patients with ACI were randomly divided into the observation group and the control group, with 42 patients in each group. Both groups were treated with urinary kallidinogenase, but the observation group was treated with ginkgo diterpene lactone glucosamine on the basis of the control group. The hemodynamics, including mean blood flow velocity (MBFV), vertebral artery blood flow (VABF) and basilar artery blood flow (BABF), neurological function,including scores of neuron specific enolase (NSE), homocysteine (Hcy), central nerve specific protein (S100-β) and National Institutes of Health Stroke Scale (NIHSS), and levels of inflammatory factor, including high sensitivity C-reactive protein (hs CRP), interleukin-6 (IL-6) and interleukin-1β (IL^-1β), were compared between the two groups before and after treatment. The clinical efficacy and incidence of adverse reactions of the two groups were observed.

Result  The total effective rate in the observation group was higher than that in the control group (95.24% vs. 80.95%, P=0.043). After treatment, the MBFV, VABF, and BABF in the observation group were all higher than those in the control group (P<0.001), the NSE, Hcy, S100-β  levels and NIHSS scores were lower than those in the control group (P<0.001), and the hs-CRP, IL-6, and IL^-1β levels were lower than those in the control group (P<0.001). There was no statistically significant difference in the incidence of adverse reactions such as facial flushing, fatigue, palpitations, rash, and gastrointestinal discomfort between the two groups of patients within 2 weeks of treatment (P>0.05).

Conclusion  Ginkgo biloba diterpene lactone glucosamine combined with urinary kallidinogenase can improve hemodynamics and neural function, inhibiting inflammatory response.

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