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Analysis of clinical efficacy of febuxostat combined with etoricoxib in the treatment of gouty arthritis

Published on Jul. 03, 2023Total Views: 1864 times Total Downloads: 871 times Download Mobile

Author: Ye HE 1, 2 Ming-Zhi HONG 3 Xiao-Chun ZHU 1

Affiliation: 1. Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China 2. Department of Rheumatology, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang Province, China 3. Department of Burn and Plastic Surgery, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang Province, China

Keywords: Gouty arthritis Febuxostat Etoricoxib Clinical efficacy Adverse reactions

DOI: 10.12173/j.issn.1004-4337.202302067

Reference: He Y, Hong MZ, Zhu XC. Analysis of clinical efficacy of febuxostat combined with etoricoxib in the treatment of gouty arthritis[J]. Journal of Mathematical Medicine, 2023, 36(6): 446-451. DOI: 10.12173/j.issn.1004-4337.202302067[Article in Chinese]

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Abstract

Objective To investigate the clinical efficacy of febuxostat combined with etoricoxib regimen in the treatment of gouty arthritis (GA).

Methods A total of 180 patients with GA admitted to The First Affiliated Hospital of Wenzhou Medical University from April 2020 to September 2022 were included as the analysis subjects, and the patients were divided into control group and observation group, with 90 cases in each group. The control group was treated with etoricoxib, and the observation group was treated with febuxostat combined with etoricoxib. After a one-week course of treatment, the two groups of GA patients were compared in terms of clinical efficacy, pain degree, uric acid (UA), erythrocyte sedimentation rate (ESR), C reactive protein (CRP) indexes and adverse reactions.

Results  The clinical efficacy evaluation of gouty arthritis in the observation group was higher than that in the control group (96.67% vs. 66.67%, P<0.001). The visual pain simulation score (VAS) decreased in both groups, and the score of patients in the observation group was significantly lower than that in the control group (1.18±0.58 vs. 2.67±0.92, P<0.001). UA, ESR and CRP indexes decreased in both groups, and the indexes of patients in the observation group were significantly lower than those in the control group (P<0.001). There was no significant difference of drug-related adverse reactions between the two groups (23.33% vs. 18.89%, P=0.363).

Conclusion  Febuxostat combined with etoricoxib has a significant effect in patients with gouty arthritis.

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