Objective To investigate the clinical efficacy of febuxostat combined with etoricoxib regimen in the treatment of gouty arthritis (GA).
Methods A total of 180 patients with GA admitted to The First Affiliated Hospital of Wenzhou Medical University from April 2020 to September 2022 were included as the analysis subjects, and the patients were divided into control group and observation group, with 90 cases in each group. The control group was treated with etoricoxib, and the observation group was treated with febuxostat combined with etoricoxib. After a one-week course of treatment, the two groups of GA patients were compared in terms of clinical efficacy, pain degree, uric acid (UA), erythrocyte sedimentation rate (ESR), C reactive protein (CRP) indexes and adverse reactions.
Results The clinical efficacy evaluation of gouty arthritis in the observation group was higher than that in the control group (96.67% vs. 66.67%, P<0.001). The visual pain simulation score (VAS) decreased in both groups, and the score of patients in the observation group was significantly lower than that in the control group (1.18±0.58 vs. 2.67±0.92, P<0.001). UA, ESR and CRP indexes decreased in both groups, and the indexes of patients in the observation group were significantly lower than those in the control group (P<0.001). There was no significant difference of drug-related adverse reactions between the two groups (23.33% vs. 18.89%, P=0.363).
Conclusion Febuxostat combined with etoricoxib has a significant effect in patients with gouty arthritis.
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