Objective  To determine the heavy metals and harmful elements in 216 batches of traditional Chinese medicine decoction pieces from different sources in Guizhou Province, and assess their potential risk of contamination, in order to provide a scientific basis for ensuring medication safety.

Methods  The content of lead and cadmium in traditional Chinese medicine decoction pieces were determined by graphite furnace atomic absorption spectrometry, the content of copper was determined by flame atomic absorption spectrometry, and the content of arsenicand mercury was determined by hydride generation-atomic fluorescence spectrometry. Statistical analysis was performed using SPSS 22.0 software.

Results  The contents of lead, cadmium, copper, mercury and arsenic in 45 kinds of traditional Chinese medicine decoction pieces were determined, with a detection rate of 100%. The potential risk assessment showed that there were potential risks when adults took Pheretima, Bombyx Batryticatus and Aspongopus at the maximum daily dosage, and when children took Pheretima, Bombyx Batryticatus, Aspongopus, Panax notoginseng, Cicadae Periostracum, Isatidis Folium, Lonicerae Japonicae Flos and Eupolyphaga at the maximum daily dosage.

Conclusion  This study determined the heavy metals and harmful elements in traditional Chinese medicine decoction pieces through a series of optimized methods, and conducted potential risk assessment, which had certain reference value for the control of heavy metal pollution in traditional Chinese medicine decoction pieces and ensuring medication safety.

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