Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial inflammation, joint tissue erosion, and cartilage degeneration. When the disease progresses to severe stages, it not only affects joints but also impacts vital organs such as the heart and lungs, as well as the nervous system, posing serious threats to both the physical and mental health of patients. In RA treatment, traditional Chinese medicine (TCM) demonstrates distinct advantages through its multi-targeted, multi-pathway intervention approach with relatively low rates of clinical adverse reactions. Existing research confirms that active TCM monomers, compound formulations, and external therapies can regulate Notch signaling pathway activity. This regulation downregulates inflammatory cytokine release, reduces bone tissue destruction, alleviates joint pain and other clinical symptoms, ultimately achieving effective control over RA progression. Based on this, this paper introduces the function of the Notch signaling pathway and its specific role in RA, while also exploring progress of TCM intervention research. This aims to provide a theoretical basis for therapeutic strategies targeting the Notch signaling pathway in the prevention and treatment of RA.

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