Objective  To analyze the application value of valsartan combined with bailing capsule in the treatment of proteinuria patients with chronic nephritis.

Methods  86 patients with chronic glomerulonephritis proteinuria admitted to Nanyang Central Hospital from February 2021 to February 2022 were randomly divided into observation group (n=43) and control group (n=43). The control group was treated with valsartan, the observation group was treated with valsartan+Bailing capsule, and the clinical efficacy, changes in 24-hour proteinuria quantitative level, renal function, serum indicators and adverse reaction rate of the two groups were compared.

Results  There was a statistically significant difference in the clinical efficacy between observation group and control group (95.35% vs. 81.40%, P=0.044). Two months after treatment, the level of average 24-hour proteinuria quantitative, BUN, SCr and CCr in the observation group were lower than those in the control group. IgA, IgM, IgG in the observation group were statistically higher than those in the control group. After treatment, the vital signs of patients in both groups were stable, and there were no significant allergic reactions and other adverse reactions.

Conclusion  The treatment of valsartan combined with Bailing capsule for proteinuria in patients with chronic nephritis probably has a positive effect on improving the renal function and regulating the serum immune system.

1.Bajema IM, Wilhelmus S, Alpers CE, et al. Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices[J]. Kidney Int, 2018, 93(4): 789-796. DOI: 10.1016/j.kint.2017.11.023.

2.Frontini G, Tamborini F, Porata G, et, al. Rate and predictors of chronic organ damage accrual in active lupus nephritis: a single centre experience over 18 years of observation[J]. Clin Exp Rheumatol, 2022, 40(5): 872-881. DOI: 10.55563/clinexprheumatol/ig0lu0.

3.蒋燕, 朱鹏飞. 参芪地黄汤联合缬沙坦对慢性肾小球肾炎患者细胞免疫和炎症反应的影响[J]. 陕西中医, 2023, 44(1): 72-75. [Jiang Y, Zhu PF. Effect of Shenqi Dihuang decoction combined with valsartan capsules medicine on cellular immunity and inflammatory reaction in patients with chronic glomerulonephritis[J]. Shaanxi Journal of Traditional Chinese Medicine, 2023, 44(1): 72-75.] DOI: 10.3969/j.issn.1000-7369.2023.01.017.

4.王骞, 龚学忠, 陈丽雯, 等. 滋阴凉血汤对慢性肾小球肾炎患者炎症因子及尿足细胞水平的影响[J]. 西部医学, 2023, 35(2): 208-213. [Wang Q, Gong XZ, Chen LW, et al. Effect of Ziyin Liangxue Decoction on inflammatory factors and urine podocyte in patients with chronic glomerulonephritis[J]. Medical Journal of West China, 2023, 35(2): 208-213.] DOI: 10.3969/j.issn.1672-3511.2023.02.010.

5.任永昊, 张凤花, 胡洪贞, 等. 益气健脾补肾方对脾肾气虚证慢性肾炎患者肾功能及FGF23-Klotho轴的影响[J]. 中国中西医结合肾病杂志, 2021, 22(11): 998-1000. [Ren YH, Zhang FH, Hu HZ, et al. Effect of Yiqi Jianpi Bushen Recipe on renal function and FGF23-Klotho axis in patients with chronic nephritis of spleen-kidney deficiency syndrome[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2021, 22(11): 998-1000.] DOI: 10.3969/j.issn.1009-587X.2021.11.017.

6.杨静, 申世华, 刘静静. 五苓散治疗肺肾气虚证慢性肾小球肾炎患者的临床疗效观察及对炎症因子的影响[J]. 中药新药与临床药理, 2021, 32(9): 1386-1390. [Yang J, Shen SH, Liu JJ. Observation on the clinical curative effect of Wuling powder in treating patients with chronic glomerulonephritis of lung and kidney qi deficiency and its effect on inflammatory factors[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2021, 32(9): 1386-1390.] DOI: 10.19378/j.issn.1003-9783.2021.09.021.

7.中华医学会肾脏病学分会专家组. 抗中性粒细胞胞质抗体相关肾炎诊断和治疗中国指南[J]. 中华肾脏病杂志, 2021, 37(7): 603-620. [Expert Group of Nephrology Branch, Chinese Medical Association. Chinese guidelines for the diagnosis and treatment of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis[J]. Chinese Journal of Nephrology, 2021, 37(7): 603-620.] DOI: 10.3760/cma.j.cn441217-20210107-00092.

8.Xiao T, Lü B, Tang Y. Application of clinical indices in pathological acute and chronic index prediction in lupus nephritis[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2020, 45(2): 128-133. DOI: 10.11817/j.issn.1672-7347.2020.180711.

9.Park DJ, Choi SE, Xu H, et al. Uric acid as a risk factor for progression to chronic kidney disease in patients with lupus nephritis: results from the KORNET registry[J]. Clin Exp Rheumatol, 2021, 39(5): 947-954. DOI: 10.55563/clinexprheumatol/k4rdi7.

10.徐向君. 阿托伐他汀联合缬沙坦对慢性肾炎患者hs-CRP、TNF-α、IL-6水平的影响[J]. 临床与病理杂志, 2021, 41(12): 2882-2888. [Xu XJ. Effect of atorvastatin combined with valsartan on hs-CRP, TNF-α and IL-6 levels in patients with chronic nephritis[J]. Journal of Clinical and Pathological Research, 2021, 41(12): 2882-2888.] DOI: 10.3978/j.issn.2095-6959.2021.12.021.

11.陈晖, 曹昉, 袁飞远. 肾复康胶囊结合缬沙坦胶囊对慢性肾小球肾炎疗效、肾功能、血清炎症因子影响研究[J]. 中华中医药学刊, 2021, 39(9): 177-180. [Chen H, Cao F, Yuan FY. Effects of Shenfukang capsule combined with valsartan capsule on efficacy, renal function and serum inflammatory factors in patients with chronic glomerulonephritis[J]. Chinese Archives of Traditional Chinese Medicine, 2021, 39(9): 177-180.] DOI: 10.13193/j.issn.1673-7717.2021.09.044.

12.段学峰, 朱冬红, 徐光标, 等. 肾炎舒片联合缬沙坦胶囊对老年高血压肾病微炎症状态、营养不良及肾功能的影响[J]. 中华中医药学刊, 2022, 40(2): 194-197. [Duan XF, Zhu DH, Xu GB, et al. Effect of Shenyanshu tablet combined with valsartan capsule on micro inflammation,malnutrition and renal function in elderly patients with hypertensive nephropathy[J]. Chinese Archives of Traditional Chinese Medicine, 2022, 40(2): 194-197.] DOI: 10.13193/j.issn.1673-7717.2022.02.045.

13.高勇, 闫续, 王鑫. 百令胶囊对尿毒症腹膜透析患者生存周期及腹透纤维化的影响[J]. 中国中西医结合肾病杂志, 2022, 23(4): 343-346, 381. [Gao Y, Yan X, Wang X. The effect of Bailing capsule on the life cycle and peritoneal dialysis fibrosis of uremic peritoneal dialysis patients[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2022, 23(4): 343-346, 381.] DOI: 10.3969/j.issn.1009-587X.2022.04.018.

14.赵文娟, 夏世国, 王秦. 百令胶囊辅助维持性血液透析对慢性肾衰竭尿毒症期患者微炎症状态及残余肾功能的影响[J]. 中国中西医结合肾病杂志, 2022, 23(11): 1013-1015. [Zhao WJ, Xia SG, Wang Q. The effect of Bailing capsule assisted maintenance hemodialysis on micro-inflammatory state and residual renal function in patients with chronic renal failure in uremic phase[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2022, 23(11): 1013-1015.] DOI: 10.3969/j.issn.1009-587X.2022.11.020.

15.朱远亭, 陈欣, 唐雪敏, 等. 非洛地平缓释片联合百令胶囊治疗慢性肾脏病对改善肾功能指标的影响[J]. 世界中医药, 2021, 16(11): 1746-1749. [Zhu YT, Chen X, Tang XM, et al. Effect of felodipine sustained release tablets combined with bailing capsule on improving renal function indexes in the treatment of chronic kidney disease[J]. World Chinese Medicine, 2021, 16(11): 1746-1749.] DOI: 10.3969/j.issn.1673-7202.2021.11.021.

16.褚晓文, 于杰, 张培培. 百令胶囊联合小剂量环孢素对难治性肾病综合征患者肾脏保护及免疫功能的影响[J].中国中西医结合肾病杂志, 2022, 23(8): 704-707. [Chu XW, Yu J, Zhang PP. The effect of Bailing capsule combined with low dose cyclosporine on renal protection and immune function in patients with refractory nephrotic syndrome[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2022, 23(8): 704-707.] DOI: 10.3969/j.issn.1009-587X.2022.08.015.

17.马学涛, 阎文娟. 百令胶囊结合缬沙坦对慢性肾小球肾炎肾保护作用及细胞免疫功能的影响[J]. 中华中医药学刊, 2021, 39(9): 220-223. [Ma XT, Yan WJ. Effects of Bailing capsule combined with valsartan on renal protection and cellular immune function in patients with chronic glomerulonephritis[J]. Chinese Archives of Traditional Chinese Medicine, 2021, 39(9): 220-223.] DOI: 10.13193/j.issn.1673-7717.2021.09.055.

18.杨娟娟. 缬沙坦联合百令胶囊对慢性肾小球肾炎患者血清炎症因子水平的影响[J]. 黑龙江医学, 2021, 45(13): 1416-1417. [Yang JJ. Effect of valsartan combined with bailing capsule on the level of serum inflammatory factors in patients with chronic glomerulonephritis[J]. Heilongjiang Medical Journal, 2021, 45(13): 1416-1417.] DOI: 10.3969/j.issn.1004-5775.2021.13.026.

19.李西胜, 屈建良. 百令胶囊联合缬沙坦治疗慢性肾小球肾炎疗效分析[J]. 中国药物与临床, 2021, 21(14): 2538-2540. [Li XS, Qu JL. Analysis of the efficacy of Bailing capsule combined with valsartan in the treatment of chronic glomerulonephritis[J]. Chinese Remedies & Clinics, 2021, 21(14): 2538-2540.] DOI: 10.11655/zgywylc2021.14.057.