Objective  To study the application value of low-dose CT combined with DCE-MRI in qualitative diagnosis of benign and malignant pulmonary nodules.

Method  90 patients with pulmonary nodules (a total of 130 nodular lesions) admitted to The First Affiliated Hospital of Henan University were included as research objects. All patients underwent low-dose CT examination and DCE-MRI examination, and the diagnosis was made according to the imaging results. Using pathological diagnosis results as the gold standard, the sensitivity and specificity of low-dose CT and low-dose CT+DCE-MRI in differential diagnosis of benign and malignant pulmonary nodules were calculated and compared respectively. At the same time, DCE-MRI quantitative analysis method was used to compare the DCE-MRI imaging parameters (Ve, Ktrans, Kep) of lung nodules in the benign group and malignant group, and to compare the corresponding pathological characteristics of malignant nodules and the distribution of DCE-MRI imaging parameters.

Result  The sensitivity and specificity of low-dose CT+DCE-MRI in the differential diagnosis of pulmonary nodules were 94.79% and 94.12%, respectively, higher than those of 83.33% and 79.41% under low-dose CT alone (P<0.05). In terms of Ve, Ktrans and Kep parameter values, nodules in malignant group were higher than those in benign group (P<0.05). Three parameters of patients with stage Ⅲ to Ⅳ, moderate and low tumor differentation and pleural invasion in the malignant group were significantly higher.

Conclusion  Combined application of DCE-MRI on the basis of low-dose CT can effectively improve the sensitivity and specificity of qualitative diagnosis of benign and malignant pulmonary nodules, and through statistical analysis of quantitative parameters of DCE-MRI, it can provide reliable information for the differential diagnosis of benign and malignant pulmonary nodules and the evaluation of pathological features of malignant tumors.

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