Objective  To explore the research status and trends in the field of prescription comment in China based on bibliometrics, and to reveal research hotspots in order to provide a reference for future studies.

Methods  Literature was collected from the CNKI, Wanfang, and VIP databases. Microsoft Office Excel 2021, CiteSpace 6.3.R2, and VOSviewer 1.6.20 softwares were used to conduct a visual analysis of publication volume, author and institution collaborations, highly cited literature, and keywords.

Results  A total of 2,343 articles were included. The research in prescription comment in China began in 2008, with academic achievements primarily published in pharmaceutical journals. A total of 549 authors from 386 institutions participated in the research, though collaborations were mostly confined within the same institution. High-impact literature mainly focused on the practical application of prescription comment in medical institutions. Keywords co-occurrence analysis indicated that the implementation objects mainly included antibacterial drugs, outpatient prescriptions, pediatric clinics, traditional Chinese patent medicines and simple preparations, irrational prescriptions, irrational drug use, and Chinese herbal pieces. Cluster analysis obtained 10 meaningful categories. Keywords emergence analysis showed that the clinical intervention effect of prescription comment has become a research hotspot in recent years.

Conclusion  Currently, rich research results have been achieved in the field of prescription comment in China, but the academic attention has decreased in recent years. In the future, collaborations between different institutions should be strengthened, and the implementation of real-time prescription comment should be explored. Meanwhile, future research should focus on the medication for special populations and specific diseases to promote the high-quality development of research on this field.

1. 杨丽娟, 甄健存, 张威, 等. 《处方点评标准》制订与解析 [J]. 医药导报, 2025, 44(3): 400-403. [Yang LJ, Zhen JC, Zhang W, et al. Formulation and interpretation of prescription evaluation standard[J]. Herald of Medicine, 2025, 44(3): 400-403.] DOI: 10.3870/j.issn.1004-0781.2025.03.010.

2. 卫生部, 国家中医药管理局, 总后勤部卫生部. 卫生部 国家中医药管理局 总后勤部卫生部关于印发《医疗机构药事管理规定》的通知（卫医政发〔2011〕11号）[EB/OL]. (2011-03-30) [2025-04-01]. https://www.nhc.gov.cn/wjw/gfxwj/201103/3df77cb6091b4694be3afd8fcd68a4b5.shtml.

3. 中国医院协会. 医疗机构药事管理与药学服务 第4-9部分: 药事管理 处方点评 T/CHAS 20-4-9-2023[S/OL]. (2024-01-05) [2025-04-01]. https://www.cha.org.cn/site/content/f964553759710b2147552d5a49064d4e.html.

4. 尹昀东, 张颢龄, 高蕊. 基于处方点评与处方分析探讨中成药合理用药的问题与现状[J]. 中国新药杂志, 2023, 32(4): 364-371. [Yin YD, Zhang HL, Gao R. Discussion on the problem and current situation of the use of Chinese patent medicine based on literature of prescription comment and prescription analysis[J]. Chinese Journal of New Drugs, 2023, 32(4): 364-371.] DOI: 10.3969/j.issn.1003-3734.2023.04.005.

5. Spigelmyer A, Howard C, Rybakov I, et al. Impact of clinical pharmacist discharge prescription review on the appropriateness of antibiotic therapy: a retrospective comparison[J]. Int J Clin Pharm, 2023, 45(3): 769-773. DOI: 10.1007/s11096-022-01503-7.

6. Gan J, Cai Q, Galer P, et al. Mapping the knowledge structure and trends of epilepsy genetics over the past decade: a co-word analysis based on medical subject headings terms[J]. Medicine, 2019, 98(32): e16782. DOI: 10.1097/MD.0000000000016782.

7. Wei T, Jin Q. Research trends and hotspots in exercise interventions for liver cirrhosis: a bibliometric analysis via CiteSpace[J]. Medicine, 2024, 103(28): e38831. DOI: 10.1097/MD.0000000000038831.

8. 刘少华, 舒成仁, 张松, 等. 特征图谱研究现状及脉络的文献计量学分析[J]. 中国药业, 2025, 34(13): 48-54. [Liu SH, Shu CR, Zhang S, et al. Bibliometric analysis of the research status and context of characteristic chromatogram[J]. China Pharmaceuticals, 2025, 34(13): 48-54.] DOI: 10.3969/j.issn.1006-4931.2025.13.011.

9. Kang Q, Ding Y. A bibliometric analysis of global research trends of exercise in oncology during the past three decades[J]. J Clin Nurs Res, 2024, 8(4): 219-224. DOI: 10.26689/JCNR.V8I4.6787.

10. Hou J, Yang X, Chen C. Measuring researchers' potential scholarly impact with structural variations: four types of researchers in information science (1979-2018)[J]. PLoS ONE, 2020, 15(6): e0234347. DOI: 10.1371/journal.pone.0234347.

11. 何妙翠, 韩琴, 马声磊. 传染病医院门诊处方点评及不合理处方类型的帕累托图分析[J]. 临床合理用药, 2024, 17(3): 150-153, 160. [He MC, Han Q, Ma SL. Review of outpatient prescriptions in infectious disease hospitals and pareto chart analysis of unreasonable prescription types[J]. Chinese Journal of Clinical Rational Drug Use, 2024, 17(3): 150-153, 160.] DOI: 10.15887/j.cnki.13-1389/r.2024.03.041.

12. 卫生部. 处方管理办法（中华人民共和国卫生部令第53号）[EB/OL]. (2007-03-13) [2025-04-01]. https://www.nhc.gov.cn/bgt/pw10704/200705/5ea52ce203824b259f4f0d38712be093.shtml.

13. 卫生部. 卫生部关于印发《医院处方点评管理规范（试行）》的通知（卫医管发〔2010〕28号）[EB/OL]. (2010-02-10) [2025-04-01]. https://www.nhc.gov.cn/yzygj/c100067/201003/cab97504075048a183ffa73809db3ad1.shtml.

14. 卞婧, 魏丽艳, 张威, 等. 2018—2020年北京地区区域性处方点评中儿童专科医院处方合理性分析[J]. 医药导报, 2022, 41(5): 713-717. [Bian J, Wei LY, Zhang W, et al. Rationality analysis of prescriptions of children's hospitals in regional prescription reviews in Beijing from 2018 to 2020[J]. Herald of Medicine, 2022, 41(5): 713-717.] DOI: 10.3870/j.issn.1004-0781.2022.05.022.

15. Xie H, Zhang H, Peng J, et al. Prospective prescription review system promotes safe use of analgesics, improves clinical outcomes, and saves medical costs in surgical patients: insights from Nanjing Drum Tower Hospital[J]. Adv Ther, 2022, 39(1): 441-454. DOI: 10.1007/s12325-021-01935-z.

16. 金锐, 赵奎君, 郭桂明, 等. 中成药临床合理用药处方点评北京共识[J]. 中国中药杂志, 2018, 43(5): 1049-1053. [Jin R, Zhao KJ, Guo GM, et al. Expert consensus on prescription comment of Chinese traditional patent medicine for promoting the rational use of drugs in Beijing[J]. China Journal of Chinese Materia Medica, 2018, 43(5): 1049-1053.] DOI: 10.19540/j.cnki.cjcmm.2018.0036.

17. 金锐, 王宇光, 薛春苗, 等. 中成药处方点评的标准与尺度探索（十）: 儿童用药[J]. 中国医院药学杂志, 2017, 37(11): 1003-1008. [Jin R, Wang YG, Xue CM, et al. The exploration on criteria and compromise in the prescription review of Chinese patent medicines X: medication for children[J]. Chinese Journal of Hospital Pharmacy, 2017, 37(11): 1003-1008.] DOI: 10.13286/j.cnki.chinhosppharmacyj.2017.11.01.

18. 金锐, 王宇光, 薛春苗, 等. 中成药处方点评的标准与尺度探索（七）: 中西药相互作用[J]. 中国医院药学杂志, 2015, 35(19): 1713-1718. [Jin R, Wang YG, Xue CM, et al. Exploration on criteria and compromise in prescription review of Chinese patent medicines Ⅶ: interaction with western medicine[J]. Chinese Journal of Hospital Pharmacy, 2015, 35(19): 1713-1718.] DOI: 10.13286/j.cnki.chinhosppharmacyj.2015.19.01.

19. 冯双, 杨明娜, 韩凤. 2017年北京社区卫生服务中心处方集中点评结果[J]. 中国药物经济学, 2020, 15(3): 55-58. [Feng S, Yang MN, Han F. Prescriptive review results in the Beijing community health service centers in 2017[J]. China Journal of Pharmaceutical Economics, 2020, 15(3): 55-58.] DOI: 10.12010/j.issn.1673-5846.2020.03.013.

20. 林平, 甄健存, 赵怀全, 等. 北京地区11家医疗机构处方点评工作开展状况调研与分析[J]. 临床药物治疗杂志, 2016, 14(6): 30-33. [Lin P, Zhen JC, Zhao HQ, et al. Investigation and analysis of prescription comment working status in eleven medical institutions of Beijing[J]. Clinical Medication Journal, 2016, 14(6): 30-33.] DOI: 10.3969/j.issn.1672-3384.2016.06.007.

21. 孙芳艳, 张占杰, 张国杰, 等. 北京协和医院2015—2019年门急诊抗菌药物处方点评结果与分析[J]. 中国感染控制杂志, 2021, 20(4): 346-350. [Sun FY, Zhang ZJ, Zhang GJ, et al. Assessment results and analysis on outpatient and emergency antimicrobial prescriptions in Peking Union Medical College Hospital from 2015 to 2019[J]. Chinese Journal of Infection Control, 2021, 20(4): 346-350.] DOI: 10.12138/j.issn.1671-9638.20217407.

22. Palms DL, Hicks LA, Bartoces M, et al. Comparison of antibiotic prescribing in retail clinics, urgent care centers, emergency departments, and traditional ambulatory care settings in the United States[J]. JAMA Intern Med, 2018, 178(9): 1267-1269. DOI: 10.1001/jamainternmed.2018.1632.

23. Wushouer H, Du K, Chen S, et al. Evaluation of prescription review and feedback policy on rational antibiotic use in primary healthcare settings in Beijing, China: a qualitative study using the theoretical domains framework and the behaviour change wheel[J]. JAC Antimicrob Resist, 2023, 5(6): dlad128. DOI: 10.1093/jacamr/dlad128.

24. 沈爱宗, 张圣雨, 陈泳伍, 等. 我院多部门协作处方点评模式在重点监控药品管理中的实践[J]. 中国药房, 2020, 31(13): 1646-1649. [Shen AZ, Zhang SY, Chen YW, et al. Practice of multidisciplinary collaborative prescription review mode in key monitored drugs management in our hospital[J]. China Pharmacy, 2020, 31(13): 1646-1649.] DOI: 10.6039/j.issn.1001-0408.2020.13.19.

25. 袁舒敏, 高燕萍, 王晓芸, 等. 中药饮片处方点评[J]. 医药导报, 2019, 38(9): 1226-1229. [Yuan SM, Gao YP, Wang XY, et al. Prescription evaluation on the traditional Chinese medicine decoction pieces[J]. Herald of Medicine, 2019, 38(9): 1226-1229.] DOI: 10.3870/j.issn.1004-0781.2019.09.023.

26. Wen Q, Yang C, Deng B, et al. Characterization of children's prospective prescription review and exploration of factors influencing the success of interventions[J]. Ther Adv Drug Saf, 2025, 16: 20420986241311448. DOI: 10.1177/20420986241311448.