Objective  To explore the clinical significance and application value of oxidative stress score in patients with acute myocardial infarction (AMI) undergoing interventional therapy.

Methods  The clinical data of AMI patients who received interventional therapy in Tongren People's Hospital from January 2020 to December 2021 were retrospectively analyzed. The patients were divided into the low oxidative stress score group and the high oxidative stress score group according to the median value of oxidative stress score. The indicators such as blood routine, coagulation function, cardiac markers and blood biochemistry of the two groups of patients were compared by χ² test or Fisher's exact test. Univariate and multivariate Logistic regression analyses were applied to analyze the risk factors for poor prognosis in AMI patients undergoing interventional therapy.

Results  A total of 511 patients were included, among whom 371 were male (72.60%) and 140 were female (27.40%). There were statistically significant differences between the low oxidative stress score group and the high oxidative stress score group in terms of red blood cells, fibrin degradation products, brain natriuretic peptide precursors, troponin T, myoglobin, blood urea nitrogen, direct bilirubin, albumin and cholesterol, etc. (P<0.05). The results of multivariate Logistic regression analysis showed that high oxidative stress score (OR=1.754, 95%CI: 1.147-2.684, P=0.01) was a risk factor for poor prognosis in AMI patients undergoing interventional therapy.

Conclusion  This study elucidated that oxidative stress score demonstrated significant clinical significance and application value for predicting the prognosis of interventional therapy in AMI patients.

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