Objective To investigate the clinical efficacy of febuxostat combined with etoricoxib regimen in the treatment of gouty arthritis (GA).

Methods A total of 180 patients with GA admitted to The First Affiliated Hospital of Wenzhou Medical University from April 2020 to September 2022 were included as the analysis subjects, and the patients were divided into control group and observation group, with 90 cases in each group. The control group was treated with etoricoxib, and the observation group was treated with febuxostat combined with etoricoxib. After a one-week course of treatment, the two groups of GA patients were compared in terms of clinical efficacy, pain degree, uric acid (UA), erythrocyte sedimentation rate (ESR), C reactive protein (CRP) indexes and adverse reactions.

Results  The clinical efficacy evaluation of gouty arthritis in the observation group was higher than that in the control group (96.67% vs. 66.67%, P<0.001). The visual pain simulation score (VAS) decreased in both groups, and the score of patients in the observation group was significantly lower than that in the control group (1.18±0.58 vs. 2.67±0.92, P<0.001). UA, ESR and CRP indexes decreased in both groups, and the indexes of patients in the observation group were significantly lower than those in the control group (P<0.001). There was no significant difference of drug-related adverse reactions between the two groups (23.33% vs. 18.89%, P=0.363).

Conclusion  Febuxostat combined with etoricoxib has a significant effect in patients with gouty arthritis.

1.王瑞云, 石志敏, 张军, 等. 巨刺法联合耳穴贴压及塞来昔布胶囊治疗湿热蕴结型急性单侧痛风性关节炎的疗效观察[J]. 广州中医药大学学报, 2022, 39(2): 339-344. [Wang RY, Shi ZM, Zhang J, et al. Observation on the curative effect of opposing needling combined with auricular point pressing and celecoxib caspules in the treatment of acute unilateral gouty arthritis with damp heat accumulation type[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2022, 39(2): 339-344.] DOI: 10.13359/j.cnki.gzxbtcm.2022.02.020.

2.刘芳, 樊虹, 李贞祥. 清热祛湿止痛方联合经络段放线法治疗急性痛风性关节炎的疗效观察[J]. 中国中医急症, 2022, 31(3): 493-496. [Liu F, Fan H, Li ZX. Observation on the curative effect of Qingre Qushi Zhitong Prescription combined with meridian segment threading method in the treatment of acute gouty arthritis[J]. Journal of Emergency in Traditional Chinese Medicine, 2022, 31(3): 493-496.] DOI: 10.3969/j.issn.1004-745X.2022.03.034.

3.陈国珍, 黄慧, 陈文华, 等. 四黄冰舒膏治疗急性痛风性关节炎疗效观察[J]. 海南医学, 2021, 32(19): 2499-2502. [Chen GZ, Huang H, Chen WH, et al. Clinical efficacy of Sihuang Bingshu Ointment in the treatment of acute gouty arthritis[J]. Hainan Medical Journal, 2021, 32(19): 2499-2502.] DOI: 10.3969/j.issn.1003 -6350.2021.19.013.

4.范晓琳, 杨小华, 周晓, 等. 黄连素辅助治疗急性痛风性关节炎的疗效及对炎性因子水平的影响[J]. 实用医学杂志, 2021, 37(18): 2413-2417, 2422. [Fan XL, Yang XH, Zhou X, et al. Clinical efficacy of berberine in treatment of acute gouty arthritis and its effect on serum levels of inflammation factors[J]. The Journal of Practical Medicine, 2021, 37(18): 2413-2417, 2422.] DOI: 10.3969/j.issn.1006-5725.2021.18.021.

5.段红艳. 非布司他联合双氯芬酸钠治疗痛风性关节炎疗效及安全性分析[J]. 创伤与急危重病医学, 2021, 9(1): 72-74. [Duan HY. Efficacy and safety analysis of febuxostat combined with diclofenac sodium in the treatment of gouty arthritis[J]. Trauma and Critical Care Medicine, 2021, 9(1): 72-74.] DOI: 10.16048/j. issn.2095-5561.2021.01.19.

6.陶江涛, 张敏, 刘方, 等. 薏苡附子败酱方对痛风性关节炎(湿热痹阻证)患者疗效、关节功能、血清促炎因子的研[J]. 中医药信息, 2021, 38(4): 72-76. [Tao JT, Zhang M, Liu F, et al. Effects of Yiyi Fuzi Baijiang Formula on curative efficacy, joint function and serum proinflammatory factors in patients with gout arthritis (impediment of dampness-heat)[J]. Information on Traditional Chinese Medicine, 2021, 38(4): 72-76.] DOI: 10.19656/j.cnki.1002-2406.210415.

7.曹诗丹, 徐伟, 孙维峰, 等. 中西医结合治疗痛风性关节炎的临床疗效[J]. 西部中医药, 2020, 33(9): 95-97. [Cao SD, Xu W, Sun WF, et al. Clinical effects of integrative medicine in treating gouty arthritis[J]. Western Journal of Traditional Chinese Medicine, 2020, 33(9): 95-97.] DOI: 10.12174/j.issn. 1004-6852.2020.09.27.

8.王平江. 中西医结合治疗急性痛风性关节炎的临床疗效及对血清炎症因子的影响[J]. 贵州医药, 2020, 44(11): 1783-1784. [Wang PJ. Clinical efficacy of integrated traditional Chinese and Western medicine in the treatment of acute gouty arthritis and its effect on serum inflammatory factors[J]. Guizhou Medical Journal, 2020, 44(11): 1783-1784.] DOI: 10.3969/j.issn.1000-744X.2020.11.050.

9.魏艳红, 李文建. 循经取五腧穴针刺疗法对湿热蕴结型痛风性关节炎患者的临床疗效[J]. 中医药信息, 2020, 37(6): 114-118. [Wei YH, Li WJ. Effect of needling Five-Shu acupoints along meridians on serum inflammatory factors in patients with gouty arthritis of dampness-heat accumulation[J]. Information on Traditional Chinese Medicine, 2020, 37(6): 114-118.] DOI: 10.19656 /j.cnki.1002-2406.200174.

10.刘琪, 赵恒侠, 楚淑芳. 荷叶饮治疗痛风性关节炎间歇期高尿酸血症患者的疗效观察[J]. 广州中医药大学学报, 2022, 39(6): 1280-1284. [Liu Q, Zhao HX, Chu SF. Curative effect of Heye Decoction for the treatment of gouty arthritis patients with intermittent hyperuricemia[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2022, 39(6): 1280-1284.] DOI: 10.13359/j.cnki.gzxbtcm.2022.06.010.

11.李倩, 底胜霞, 张意侗, 等. 凉血活血方敷贴治疗湿热蕴结型急性痛风性关节炎的疗效及对Th17/Treg细胞平衡的影响[J]. 中国医院用药评价与分析, 2022, 22(9): 1085-1088. [Li Q, Di SX, Zhang YT, et al. Efficacy of Liangxue Huoxue Recipe application in the treatment of acute gouty arthritis of dampness-heat accumulation type and its effect on Th17/Treg cell balance[J].Evaluation and Analysis of Drug-Use in Hospitals of China, 2022, 22(9): 1085-1088.] DOI: 10.14009/j.issn.1672-2124.2022.09.014.

12.瞿佶, 俞泓波, 蔡程辰, 等. 中医综合治疗急性痛风性关节炎(湿热蕴结证)的疗效观察[J]. 中国中医急症, 2022, 31(5): 843-846. [Qu J, Yu HB, Cai CC, et al. Observation on clinical efficacy of comprehensive treatment of TCM in the acute gouty arthritis of damp-heat accumulation type[J]. Journal of Emergency in Traditional Chinese Medicine, 2022, 31(5): 843-846.] DOI: 10.3969/j.issn.1004-745X.2022.05.024.

13.李东升, 黎声飞, 吕静, 等. 美洛昔康联合小剂量秋水仙碱治疗痛风性关节炎疗效及对患者炎性指标和红细胞沉降率的影响[J]. 广东医学, 2020, 41(14): 1442-1445. [Li DS, Li SF, Lyu J, et al. Efficacy of meloxicam combined with colchicine in treatment of gout arthritis and its effect on their inflammatory indexes and erythrocyte sedimentation rate[J]. Guangdong Medical Journal, 2020, 41(14): 1442-1445.] DOI: 10.13820/j.cnki.gdyx.20193100.

14.俞泓波, 瞿佶, 吴弢, 等. 中医综合治疗对老年湿热蕴结型急性痛风性关节炎患者的临床疗效[J]. 老年医学与保健, 2022, 28(1): 39-42, 47. [Yu HB, Qu J, Wu T, et al. Clinical effect of comprehensive treatment of traditional Chinese medicine on elderly patients with acute gouty arthritis of dampness-heat accumulation type[J]. Geriatrics & Health Care, 2022, 28(1): 39-42, 47.] DOI: 10.3969/j.issn.1008-8296.2022.01.009.

15.戴思思, 刘琨, 费秀丽, 等. 阳痛方联合塞来昔布治疗急性痛风性关节炎湿热蕴结型的疗效研究[J]. 新疆医科大学学报, 2022, 45(5): 564-568. [Dai SS, Liu K, Fei XL, et al. Observation on curative effect of Yangtong Prescription combined with cele-coxib in the treatment of acute gouty arthritis with damp-heat accumulation[J]. Journal of Xinjiang Medical University, 2022, 45(5): 564-568.] DOI: 10.3639/j.issn.1009-5551.2022.05.017.

16.林晓烁, 尹辛成, 徐光勋, 等. 白虎加桂枝汤联合苯溴马隆片治疗高尿酸血症合并急性痛风性关节炎的疗效及其作用机制[J]. 世界中西医结合杂志, 2021, 16(4): 727-730, 735. [Lin XS, Yin XC, Xu GX, et al. Therapeutic effect and mechanism of Baihu and Guizhi Decoction combined with benbromarone in the treatment of hyperuricemia with acute gouty arthritis[J]. World Journal of Integrated Traditional and Western Medicine, 2021, 16(4): 727-730, 735.] DOI: 10.13935/j.cnki.sjzx.210428.

17.韩洁茹, 解颖, 常佳怡, 等. 资生肾气丸方化裁治疗急性痛风性关节炎临床疗效分析[J]. 长春中医药大学学报, 2021, 37(1): 108-110. [Han JR, Xie Y, Chang JY, et al. Analysis of clinical efficacy of Zisheng Shenqi Pills in flexibly medicating and treating acute gouty arthritis[J]. Journal of Changchun University of Chinese Medicine, 2021, 37(1): 108-110.] DOI: 10.13463/j.cnki.cczyy.2021.01.029.

18.臧波, 周慧敏. 蠲痹历节清方联合塞来昔布治疗急性痛风性关节炎湿热蕴结型疗效观察[J]. 西部中医药, 2021, 34(7): 106-107. [Zang B, Zhou HM. Clinical observation on Juanbi Lijieqing Prescription and celecoxib in treating acute gouty arthritis of damp-heat accumulation pattern[J]. Western Journal of Traditional Chinese Medicine, 2021, 34(7): 106-107.] DOI: 10.12174/j.issn.2096-9600.2021.07.27.

19.侯喆, 贺钧. 关节镜下有限清理术联合得宝松、玻璃酸钠关节腔注射治疗膝关节痛风性关节炎的疗效分析[J].中国医刊, 2021, 56(8): 905-906. [Hou Z, He J. Efficacy analysis of arthroscopic limited debridement combined with intra-articular injection of diprospan and sodium hyaluronate in the treatment of gouty arthritis of the knee joint[J]. China Journal of Medicine, 2021, 56(8): 905-906.] DOI: 10.3969/j.issn.1008-1070.2021.08.026.

20.魏从兵, 何晓玲, 李贺伟. 七叶皂苷钠联合非布司他治疗急性痛风性关节炎临床疗效观察[J]. 湖北中医药大学学报, 2021, 23(2): 95-97. [Wei CB, He XL, Li HW. Clinical observation on sodium aescinate combined with febuxostat in treatment of acute gouty arthritis[J]. Journal of Hubei University of Chinese Medicine, 2021, 23(2): 95-97.] DOI: 10.3969/j.issn.1008-987x.2021.02.27.