Objective  To investigate the effects of insulin aspart combined with insulin detemir on blood glucose control, indexes about oxidative stress, pregnancy outcome in patients with gestational diabetes mellitus (GDM).

Methods  296 patients with GDM admitted to Puyang Maternity and Child Care Centers from March 2022 to March 2023 were divided into insulin aspart + insulin detemir group (MD+DT group) and insulin aspart + biosynthetic human insulin group (MD+HC group), with 148 cases in each group. The course of treatment was 8 weeks. The fasting blood glucose (FBG), 2 hour postprandial plasma glucose (2hPG), glycosylated hemoglobin (HbAlc), inflammatory response factors (serum hs-CRP, IL-6, TNF-α), oxidative stress response indicators (serum GSH-Px, SOD, MDA) and the incidence of adverse pregnancy events of the two groups were compared before and after treatment.

Results  After 8 weeks of treatment, FBG, 2hPG, HbAlc, serum hs-CRP, IL-6 and TNF-α in MD+DT group were lower than those in MD+HC group (P<0.05), serum GSH-Px and SOD in MD+DT group were higher than those in MD+HC group (P<0.05), and serum MDA was lower than that in MD+HC group (P<0.05). The incidence of adverse pregnancy events in MD+DT group was lower than that in MD+HC group (8.11% vs. 18.92%, P=0.011).

Conclusion  Insulin aspart combined with insulin detemir is better than insulin aspart combined with biosynthetic human insulin for blood glucose control effect in pregnant women with GDM, and can better inhibit micro-inflammatory response and oxidative stress response in pregnant women on the basis of improving the blood glucose control level, so as to improve the pregnancy outcome.

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