Objective  By using entropy weight TOPSIS method, to evaluate the rationality of prophylactic antibiotics used in perioperative period of cesarean section before and after the intervention of clinical pharmacists.

Methods  Based on Guiding Principles for Clinical Application of Antibiotics (2015 edition), drug instructions, and related guidelines, rules for evaluation of prophylactic application of antibiotics in perioperative period of cesarean section were established based on entropy weight TOPSIS. Furthermore, the rationality of cesarean section cases in The Third Affiliated Hospital of Xinxiang Medical University in the first quarter of 2021 and the first quarter of 2022 were evaluated.

Results  The proximity degree (Ci) between the evaluated cases and the optimal plan was not less than 0.6 increased from 4 cases (3.48%) to 38 cases (38%), with a statistically significant difference (P<0.05). Before and after the intervention of clinical pharmacists, the maximum entropy weight of the ten evaluation indexes was drug administration time, with the weights of 0.684 3 and 0.751 7.

Conclusions  Based on TOPSIS method of entropy weight, the rationality of the prophylactics antibiotics use in perioperative period of cesarean section can be quantitatively evaluated by synthesizing multiple indicators, and the effect of clinical pharmacists' intervention can also be evaluated in a practical way.

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