Objective  To analyze the medication patterns of national patented traditional Chinese medicine compounds with liver and stomach protection effects, and provide reference for the regulation of liver and stomach disharmony in traditional Chinese medicine and the development of new products.

Methods  The national patented traditional Chinese medicine compounds with liver and stomach protection effects published on China Patent Announcement website and CNKI were searched and collected. Traditional Chinese medicine inheritance computing platform, IBM SPSS Modeler 18.0 and SPSS 27.0 softwares were used to analyze the frequency of medication, drug flavor, meridian tropism and efficacy, and conduct compatibility association rule analysis and cluster analysis.

Results  A total of 127 traditional Chinese medicine compound patents were included, involving 444 kinds of drugs. Among these, 24 high-frequency drugs were identified, such as Poria, Puerariae Lobatae Radix, Glycyrrhizae Radix Et Rhizoma, Lycii Fructus, Crataegi Fructus, etc. The main drugs used were tonic drugs. The drug flavors were mainly sweet, the drug natures were mainly mild and warm, mostly return to liver, spleen, stomach, and lung channels. Association rules analysis showed that there were 28 highly related drug pairs such as "Puerariae Lobatae Radix + Semen Hoveniae". There were four commonly used drug combinations.

Conclusion  Based on data mining, this study found that national patented traditional Chinese medicine compound products with liver and stomach protective effects had the effects of soothing the liver and spleen, and replenishing deficiency, which can provide reference for the development of new products.

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