Fibrous dysplasia of bone (FD) is a non-hereditary disease characterized by tumor-like hyperplasia of fibrous and bone tissue, currently treated mainly with surgery. A male case of extensive FD of proximal femur combined with pathological fracture was reported. The scope of FD invasion involved femoral head, femoral neck, intertrochanteric femur and proximal lower trochanter of femur. After treatment with lesion curettage + specially designed channel allogeneic fibula strip support bone grafting + compression bone grafting + locked bone plate internal fixation, the patient’s physiological length of lower limb and trunk angle of neck recovered. At 25 months of follow-up, the patient had a good recovery of functional activity in the lower extremity, with no pain or recurrence of FD observed in the affected limb.

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