Objective  To analyze the research status, hotspots and development trends of research on the correlation between senile sarcopenia and mitochondria from 2008 to 2024, and to provide references for future studies in this field.

Methods  The literature on the correlation between senile sarcopenia and mitochondria included in the Web of Science Core Collection database from January 1, 2008 to December 31, 2024 were retrieved. The Bibliometrix package of R 4.2.0 software was used to conduct quantitative and visual analyses of the publishing countries, cooperative networks, authors, institutions, journals, highly cited article, keywords and citation frequency of literature, and the H-index was used to analyze the academic influence of the authors.

Results  A total of 1 219 articles were included. The number of published articles from 2008 to 2024 generally showed an upward trend. The top three countries in terms of cumulative publications were the United States, China and Italy. The top three journals in terms of publications were Journal of Cachexia, Sarcopenia and Muscle, International Journal of Molecular Sciences, and Experimental Gerontology. The top six authors in the H-index ranking were Marzetti E, Calvani R, Picca A,Van Remmen H, Leeuwenburgh C and Bernabel R. The most frequently cited references were "Sarcopenia: aging-related loss of muscle mass and function". The top five keywords with the highest frequency of occurrence were skeletal muscle, sarcopenia, oxidative stress, exercise, and expression.

Conclusion  The research field of the correlation between senile sarcopenia and mitochondria showed a good development trend. In the future, it is necessary to strengthen cross-national, cross-institutional and cross-disciplinary cooperation, and focus on the exploration of the influence of mitochondrial fusion proteins on mitochondrial function, as well as the intervention effect of diet and exercise on senile sarcopenia.

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