Objective  To investigate the correlation between systemic immune inflammation index (SII) , clinicopathologic features and pelvic lymph node metastasis in early-stage cervical cancer.

Methods The clinical data of 182 early-stage cervical cancer patients who underwent open or laparo-scopic wide hysterectomy + pelvic lymphadenectomy between January 2016 and December 2021 at the Second Affiliated Hospital of Zhengzhou University were retrospectively analyzed to calculate the opti-mal cutoff value of SII by receiver operating characteristic (ROC) curve, and the high-risk factors for lymph node metastasis of cervical cancer were analyzed, multivariate logistic regression analysis was used to investigate independent risk factors for lymph node metastasis of cervical cancer.

Results  Among 182 patients, 46 pelvic lymph nodes were involved with metastasis, for a metastatic rate of 25.27%. According to univariate analysis, lymph node metastasis was associated with SII ≥ 359.15, vas-culature tumor thrombus positivity, tumor ≥ 2 cm, depth of cervical stromal invasion ≥ ⅔ fibromuscular layer, and preoperative clinical stage II (P < 0.05). The results of multivariate logistic regression analysis showed that SII ≥ 359.15, vasculature tumor thrombus positivity, tumor ≥ 2 cm, and cervical stromal invasion depth ≥ ⅔ fibromuscular layer were independent risk factors for lymph node metastasis (P < 0.05).

Conclusion  SII is a sensitive preoperative predictor of the presence or absence of lymph node metastasis and is an independent risk factor for lymph node metastasis in early-stage cervical cancer.

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