Methylation-related prognosis of TBX2 gene in head and neck squamous cell carcinoma

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Affiliation: 1. Institute of Biological Medicine, Hubei University of Medicine, Shiyan 442000, Hubei Province, China 2. Institute of Life Sciences, Taihe Hospital, Affliated Hospital of Hubei University of Medicine, Shiyan 442000, Hubei Province, China 3. Hubei Key Laboratory of Embryonic Stem Cell Research, Shiyan 442000, Hubei Province, China

Keywords: TBX2 Methylation Head and neck squamous cell carcinoma Prognosis

DOI: 10.12173/j.issn.1004-4337.202312090

Reference: Zan YX, Ding Y. Methylation-related prognosis of TBX2 gene in head and neck squamous cell carcinoma[J]. Journal of Mathematical Medicine, 2024, 37(2): 100-107. DOI: 10.12173/j.issn.1004-4337.202312090[Article in Chinese]  Copied

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Abstract

Objective To explore the relationship between TBX2 gene and head and neck squamous cell carcinoma (HNSCC), and to analyze the value of methylation prognosis.

Methods The UCSC Xena database, Gene Expression Omnibus (GEO) database, Human Protein Atlas (HPA) database and UALCAN database were comprehensively used to explore the expression, DNA methylation and clinical correlation of TBX2 gene, and gene set enrichment analysis (GSEA) method was used to enrich the signaling pathways involved in TBX2 gene in HNSCC.

Results TBX2 gene was highly expressed in patients with HNSCC, and there was no significant difference in overall survival (OS) in patients with HNSCC in TBX2 gene high expression group and low expression group. However, the expression of TBX2 in HNSCC was related to clinical grade and stage. Low methylation levels at certain cg sites of the TBX2 gene were closely associated with poor OS and progression free survival (PFS). The results of GSEA showed that TBX2 gene was mainly involved in calcium signaling pathway, adhesion plaque, proteasome and other pathways.

Conclusion TBX2 gene can be a biomarker for the specific diagnosis and prognosis of HNSCC.

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References

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