The Notch signaling pathway plays a central role in the proliferation, invasion, drug resistance, and maintenance of cancer stem cells in prostate cancer. Active components of traditional Chinese medicine (TCM) inhibit tumor stemness, suppress epithelial-mesenchymal transition (EMT), autophagy, and tumor immune evasion, while enhancing apoptosis and chemotherapy sensitivity of prostate cancer cells through regulating the expression of Notch receptor 1 (Notch1), hairy and enhancer of split (Hes), Jagged ligand, and other related molecules, as well as blocking γ-secretase activity. This review aims to summarize recent advances in the study of TCM active components targeting the Notch pathway for prostate cancer treatment, elucidate their mechanisms of action, provide novel insights for TCM-based interventions in prostate cancer, and promote the development of TCM resources and optimization of precision treatment strategies.

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