Objective  To study the inherent law between factors in the pharmaceutical preparation production process, and explore the application of rough set theory to seek the optimal process plan method.

Methods  Take the classic recipe Siwu decoction as an example. Based on preprocessing data of the orthogonal design experiment, the decision table was established, and the rough set rule model was used to analyze.

Results  When the factor levels of the extraction time, the amount of water and the extraction times of Siwu decoction were gradually increased, the content of polysaccharide showed an increasing trend. When the extraction time was 1.5 hours, the amount of water was 1 : 20 and the extraction times were 2, the experimental results were the best and the best combination of three factors and three levels to optimize the extraction process of Siwu decoction.

Conclusion  Rough set theory can be applied to explore the correlation among factors of pharmaceutical production process and the correlation between factors and test results, to reveal its inherent dynamic law more comprehensively and provide a novel research method to further improve the quality of pharmaceutical preparations.

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