Pain is the main clinical manifestation of lumbar disc herniation (LDH), and it is also one of the main characteristics of inflammatory response. Pain is easy to become chronic and affect the cognition and emotion of patients. Under the stimulation of inflammatory mediators, the transient receptor potential A1 (TRPA1) ion channel is activated to participate in the generation of pain and inflammation, and the long-term vicious cycle acts on the body to cause discomfort, making it one of the anti-inflammatory and analgesic targets. In the treatment of pain, Chinese medicine has the advantages of significant curative effect and small side effects. This paper deeply discussed the molecular mechanism of traditional Chinese medicine intervention in LDH based on TRPA1 ion channel, which provided new ideas for clinical treatment.

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