Objective To analyze the mid-term treatment rules of the treatment plan for  flaccidity syndrome in the cluster "Yian Leiju" to provide references for future sputum related treatments.

Method  The medical cases of ancient physicians in "Yian Leiju" were collected and organized, and the prescription drugs were extracted ac-cording to the inclusion/exclusion criteria and standardized, and we applied the An-cient and Modern Consilia Cloud Platform Software (V2.3.5)  to analyze the pre-scription data by frequency statistics, cluster analysis, correlation analysis, and com-plex network to obtain the medication patterns of ancient medical doctors for the treatment of flaccidity syndrome.

Result  After screening, a total of 38 doctors were involved, 157 medical cases were included, with 166 consultations , and the total frequency of 1596 times. Commonly used Chinese medicines taste more sweet and bitter, mainly attributed to the kidney, liver meridian, high frequency drugs for an-gelica, knee, Poria, common drugs for angelica-achyranthes bidentata, tiger tib-ia-achyranthes bidentata, etc., the core prescription composition was based on Huqian Pills with addition and reduction.

Conclusion  In "Yian Leiju", the most commonly used drugs for treating flaccidity are mainly to tonify the liver and kidney, strengthen the muscles and bones supplemented by clearing away dampness and heat, and regulating qi. The treatment is based on the liver and kidneys and tonification, supplemented by clearing away heat and strengthening Yin.

1.高振梅, 徐东娟, 丁元庆. 基于营卫理论探讨痿证发病机制[J]. 中华中医药杂志, 2020, 35(12): 6185-6188.[Gao ZM, Xu DJ, Ding YQ. Discussion on the pathogenesis of flaccidity syndrome based on the theory of nu-trient qi and defensive qi[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2020, 35(12): 6185-6188.] http://qikan.cqvip.com/Qikan/Article/Detail?id=7104269387.

2.刘光华, 吴振起, 赵明山. 《黄帝内经》痿病源流及名实[J]. 中医研究, 2007, 20(3): 12-14. [Liu GH, Wu ZQ, Zhao MS. Huangdi Neijing impotence disease origin and name[J]. Traditional Chinese Medicinal Research, 2007, 20(3): 12-14.] DOI: 10.3969/j.issn.1001-6910.2007. 03.007.

3.常婷. 中国重症肌无力诊断和治疗指南(2020版)[J]. 中国神经免疫学和神经病学杂志, 2021, 28(1): 1-12. [Chang T. Chinese guidelines for diagnosis and treatment of myasthenia gravis (2020)[J]. Chinese Journal of Neuroim-munology and Neurology, 2021, 28(1): 1-12.] DOI: 10.3969/j.issn.1006-2963.2021.01.001.

4.刘益彰, 陈文康, 赵家有, 等. 《诸病源候论》导引通痹治痿内涵及术式解析[J]. 上海中医药杂志, 2022, 56(12): 50-52. [Liu YZ, Chen WK, Zhao JY, et al. Analysis on connotation and movement of Daoyin treating flaccidity by dredging Bi in general treatise on causes and symptoms of all diseases[J]. Shanghai Journal of Tradition-al Chinese Medicine, 2022, 56(12): 50-52.] DOI: 10.16305/j.1007-1334.2022.2204061.

5.季文达, 吴新凤, 陈旭, 等. 运用通督填髓法治疗痿证[J]. 中医杂志, 2022, 63(1): 82-84, 98. [Ji WD, Wu XF, Chen X, et al. Treating flaccidity syndrome with the method of unblocking the governor and filling the mar-row[J]. Journal of Traditional Chinese Medicine, 2022, 63(1): 82-84, 98.] DOI: 10.13288/j.11-2166/r.2022. 01.015.

6.何彦澄, 肖永华, 闫璞, 等. 中医医案分析方法评述[J]. 中医杂志, 2018, 59(13): 1106-1109. [He YC, Xiao YH, Yan P, et al. Review of analysis methods of Chinese medical records[J]. Journal of Traditional Chinese Medicine, 2018, 59(13): 1106-1109.] DOI: 10.13288/j.11-2166/r.2018.13.007.

7.盛增秀. 医案类聚[M]. 北京:人民卫生出版社, 2015.[Sheng ZX. Medical cases gather[M]. Beijing: People's Medical Publishing House, 2015.]

8.国家中医药管理局.痿病的诊断依据、证候分类、疗效评定——中华人民共和国中医药行业标准《中医内科病证诊断疗效标准》(ZY/T001.1-94)[J]. 辽宁中医药大学学报, 2016, 18(8): 153. [National Administration of Traditional Chinese Medicine. The diagnosis basis, syndrome classification and curative effect evaluation of impo-tence disease--The People's Republic of China on traditional Chinese medicine industry standard <standards for diagnosis and efficacy of internal diseases of traditional Chinese medicine> (ZY/T001.1-94)[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2016, 18(8): 153.] http://www.cnki.com.cn/Article/CJFDTotal-LZXB201608053.htm.

9.国家药典委员会. 中华人民共和国药典:三部[M]. 北京:化学工业出版社, 2020: 1-259. [The National Pharmaco-poeia Commission. The Pharmacopoeia of the People's Republic of China: three parts[M]. Beijing: Chemical Industry Press, 2020: 1-259.]

10.高学敏. 中药学[M]. 北京:中国中医药出版社, 2002: 1-635. [Gao XM. Science of Chinese materia medica[M]. Beijing: China Press of Traditional Chinese Medicine, 2002: 1-635.]

11.于琦, 李敬华, 李宗友, 等. 基于本体的中医医案知识服务与共享系统构建研究[J]. 中国数字医学, 2017, 12(5): 103-105. [Yu Q, Li JH, Li ZY, et al. Research on medical record knowledge service and sharing system of traditional Chinese medicine based on ontology[J]. China Digital Medicine, 2017, 12(5): 103-105.] DOI: 10.3969/j.issn.1673-7571.2017.05.034.

12.李玲, 黄银兰, 马腾. “治痿独取阳明”对4例家族性肌萎缩侧索硬化症患者临床表现的影响[J]. 时珍国医国药, 2016, 27(4): 883-885. [Li L, Huang YL, Ma T. Effect of impotence treatment on clinical manifestations of four patients with familial ALS[J]. Lishizhen Medicine and Materia Medical Research, 2016, 27(4): 883-885.] DOI: 10.3969/j.issn.1008-0805.2016.04.039.

13.黄竞杰, 杨俊兴, 陈浩雄.牛膝总皂苷治疗膝骨关节炎的药理研究进展[J].中药新药与临床药理, 2021, 32(4): 592-595. [Huang JJ, Yang JX, Chen HX. Progress in pharmacological research on total saponins of achy-ranthes bidentata in the treatment of knee osteoarthritis[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2021, 32(4): 592-595.] DOI: 10.19378/j.issn.1003-9783.2021.04.022.

14.罗江. 虎潜丸加减方治疗肾阴虚型原发性骨质疏松症骨性疼痛的疗效观察[J].湖南中医药大学学报, 2019, 39(4): 546-549. [Luo J. Clinical efficacy observation on modified Huqian pills in the treatment of bone pain of primary osteoporosis with kidney Yin deficiency syndrome[J]. Journal of Traditional Chinese Medicine University of Hunan, 2019, 39(4): 546-549.] DOI: 10.3969/j.issn.1674-070X.2019.04.024.

15.董晴, 陈明苍. 当归化学成分及药理作用研究进展[J]. 亚太传统医药, 2016, 12(2): 32-34. [Dong Q, Chen MC. Chemical composition and pharmacological research progress of angelica[J]. Asia-Pacific Traditional Medicine, 2016, 12(2): 32-34.] DOI: 10.11954/ytctyy.201602014.

16.赵烨, 杨志华, 范子璇, 等. 基于中医传承辅助平台的老年性便秘用药规律分析[J]. 山东中医杂志, 2020, 39(3): 246-251. [Zhao Y, Yang ZH, Fan ZX, et al. Analysis of medication rule of senile constipation based on the auxiliary platform of TCM inheritance and inheritance[J]. Shandong Journal of Traditional Chinese Medi-cine, 2020, 39(3): 246-251.] DOI: 10.16295/j.cnki.0257-358x.2020. 03.010.

17.王刚, 董宝强, 王树东, 等. 痿症从肝论治的理论探讨[J]. 中华中医药学刊, 2015, 33(7): 1636-1637. [Wang G, Dong BQ, Wang SD, et al. Study on the treatment of flaccidity syndrome through liver[J]. Chinese Ar-chives of Traditional Chinese Medicine, 2015, 33(7): 1636-1637.] DOI: 10.13193/j.issn.1673-7717.2015.07.029.

18.孙铁锋, 李振华.对国医大师刘柏龄治疗骨痿症的验案探析[J].当代医药论丛, 2015, 13(21): 250-251. [Sun TF, Li ZH. Analysis of the treatment of bone impotence by Liu Bailing, a master of traditional Chinese medi-cine[J]. Contemporary Medicine Forum, 2015, 13(21): 250-251.] DOI: CNKI:SUN:QYWA.0.2015-21-218.

19.朱震亨. 丹溪心法[M]. 北京：人民卫生出版社, 2005: 217-226. [Zhu ZH. Danxi Xinfa[M]. Beijing: People's Medical Publishing House, 2005: 217-226.]

20.杨凤娇,陈海燕.中药濒危野生动物资源代用品的研究现状及对策[J].中国中医药现代远程教育, 2019, 17(16): 47-49. [Yang FJ, Chen HY. Research status and strategy on endangered wild animal resources substitutes of traditional Chinese medicine herbs[J]. Chinese Medicine Modern Distance Education of China, 2019, 17(16): 47-49.] DOI: 10.3969/j.issn.1672-2779.2019.16.019.