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Research progress on the biological function of microRNA and its correlation with ovarian cancer

Published on May. 29, 2024Total Views: 1561 times Total Downloads: 543 times Download Mobile

Author: ZHOU Yuheng 1 LI Yuetong 1 ZHANG Shuaihui 2 DENG Yuchen 1 LIU Zhongyuan 1 CHEN Baijun 1 DING Lin 1, 3

Affiliation: 1. Medical Department of Xinglin College, Nantong University, Nantong 226000, Jiangsu Province, China 2. School of Public Health, Nantong University, Nantong 226000, Jiangsu Province, China 3. General Introduction to Surgery Teaching and Research Office, Medical School of Nantong University, Nantong 226000, Jiangsu Province, China

Keywords: Ovarian cancer microRNA Drug resistance Invasion Metastasis Target

DOI: 10.12173/j.issn.1004-4337.202401119

Reference: Zhou YH, Li YT, Zhang SH, Deng YC, Liu ZY, Chen BJ, Ding L. Research progress on the biological function of microRNA and its correlation with ovarian cancer[J]. Journal of Mathematical Medicine, 2024, 37(5): 385-391. DOI: 10.12173/j.issn.1004-4337.202401119[Article in Chinese]

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Abstract

Ovarian cancer (OC) is one of the three common primary malignant tumors in women, which seriously endangers the reproductive health. Due to its high concealment, susceptibility to drug resistance, and susceptibility to recurrence, the prognosis of patients is poor and the mortality rate is extremely high. MicroRNA (miRNA) is a type of small molecule single stranded non coding RNA that primarily exerts gene expression regulation at the post transcriptional level by specifically inhibiting translation or degrading target mRNA. Multiple miRNAs have been confirmed to be abnormally expressed in OC and play a core role in regulating cell migration and invasion, drug resistance, angiogenesis, and tumor microenvironment.This article reviews the biological functions of miRNA and its role in OC, in order to provide references for the diagnosis, treatment, prognosis and intervention targets of OC.

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References

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