Objective  To explore the application value of serum cartilage oligomeric matrix protein (COMP) and a disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) detection in the prediction of cardiovascular disease (CVD) risk in patients with osteoarthritis (OA).

Method  A total of 120 patients with OA were enrolled as OA group, and 120 healthy patients were selected as healthy group. The levels of COMP and ADAMTS-7 in the two groups were detected, and the index values of COMP and ADAMTS-7 were compared between the two groups. The patients in the OA group were divided into CVD group and non-CVD group, and the non-CVD group was divided into CVD low-risk group, intermediate-risk group and high-risk group, and the serum COMP and ADAMTS-7 of patients in each group were compared. The relationship between serum COMP, ADAMTS-7 and CVD pathological characteristics was analyzed in CVD group.

Result  The serum COMP (14.35±2.13 vs. 7.13±1.02, P<0.001) and ADAMTS-7 (56.54±5.23 vs. 30.13±3.15, P<0.001) were higher in the OA group than those in the healthy group, while the serum COMP (18.45±2.33 vs. 12.53±2.05, P=0.002) and ADAMTS-7 (83.25±7.34 vs. 45.15 ±5.23, P<0.001) in the CVD group were higher than those in the non-CVD group, and there were significant differences between serum COMP and ADAMTS-7 in the high-risk group of CVD and the low- and medium-risk group. In the CVD group, serum COMP (P=0.007) and ADAMTS-7 (P=0.009) were higher in the atherosclerotic severe group than in the mild to moderate group. The serum COMP (P=0.011) and ADAMTS-7 (P=0.008) in the cardiac function grade III-IV group were higher than those in the grade I-II group. The serum COMP (P<0.001) and ADAMTS-7 (P<0.001) were higher in the poor prognosis group than in the good prognosis group.

Conclusion  The detection of serum COMP and ADAMTS-7 in OA patients can provide information basis for predicting the risk degree of patients with CVD, and can also be used as an important reference index for the diagnosis and prognosis of patients with CVD.

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