In recent years, the morbidity and mortality of cardiovascular diseases have been increasing in China, and as an important pathological basis for the occurrence of heart diseases and the deterioration of heart function, myocardial fibrosis (MF) has received more and more attention. With the development of experimental methods such as high-throughput sequencing, the role of intestinal flora and its metabolites in the treatment of digestive system diseases, circulatory system diseases, and immune system diseases have gradually emerged. In this paper, the effect of short-chain fatty acids, one of the metabolites of intestinal flora, on MF,  was discussed, to provide a new direction for the prevention and treatment of MF.

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