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Research progress on the neuromodulation mechanisms of acupuncture and moxibustion analgesia based on functional magnetic resonance imaging

Published on Nov. 29, 2025Total Views: 108 times Total Downloads: 24 times Download Mobile

Author: ZHONG Huagui 1 TIAN Lu 2 XIE Hongwu 3 LIN Shangxun 4 LIAN Tiansheng 4

Affiliation: 1. Department of Rehabilitation Medicine, Nanchang County People's Hospital, Nanchang 330200, China 2. School of Acupuncture and Tuina, Jiangxi University of Chinese Medicine, Nanchang 330004, China 3.Department of Rehabilitation Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330008, China 4. Department of Rehabilitation Medicine, Wuping County Hospital, Longyan 364315, Fujian Province, China

Keywords: Functional magnetic resonance imaging Neuromodulation Acupuncture Moxibustion

DOI: 10.12173/j.issn.1004-4337.202505036

Reference: Zhong HG, Tian L, Xie HW, Lin SX, Lian TS. Research progress on the neuromodulation mechanisms of acupuncture and moxibustion analgesia based on functional magnetic resonance imaging[J]. Journal of Mathematical Medicine, 2025, 38(11): 860-867. DOI: 10.12173/j.issn.1004-4337.202505036[Article in Chinese]

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Abstract

To investigate the differences in brain effects induced by acupuncture therapy based on functional magnetic resonance imaging (fMRI) technology,this study demonstrated that different acupuncture and moxibustion techniques had distinct regulatory effects on brain regions. The therapeutic efficacy of acupuncture was closely related to needling techniques, acupoint combinations, and stimulation intensity. Its central analgesic mechanism involved changes in the functional connectivity of local brain nuclei. Special acupuncture techniques (such as electroacupuncture and fire needle) exhibited unique central nervous system regulatory effects in the treatment of specific diseases. Moxibustion (including common moxibustion, special moxibustion, and heat-sensitive moxibustion) also exerted analgesic effects by regulating brain neural activity, with differences from the central analgesic mechanisms of acupuncture. Although fMRI technology has provided technical support for the study of acupuncture neuroregulation mechanisms, the research at that time still had limitations,as including small sample sizes, non-uniform experimental designs, and the lack of pathological control groups. Future research was suggested to establish unified and standardized operating procedures, expand sample sizes, and integrate clinical treatment plans to further explore the neuroregulatory mechanisms of acupuncture analgesia,thereby providing a more solid scientific basis for the development of acupuncture.

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References

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