Objective To investigate the surgical efficacy of lung wedge resection in elderly patients with stage Ib non-small cell lung cancer.

Method  A total of 100 elderly patients with stage Ib non-small cell lung cancer admitted to Luohe Central Hospital from May 2019 to May 2021 were regarded as research subjects. The patients in the control group were treated by lobectomy, and the patients in the experimental group were treated by lung wedge resection, the changes of surgery-related indicators, postoperative complications, stress indicators and inflammatory response indicators before and after surgery were compared between the two groups, and the survival rate and disease recurrence of the two groups were recorded at one year after surgery.

Result  Except for the comparison of hospital stays, the surgical indexes of the experimental group were better than those of the control group. Compared with the preoperative comparison, the levels of bradykinin (BK), prostaglandin E2 (PGE2) and substance P (SP) in both groups were increased, but the indexes of experimental group were lower than those of the control group (P<0.05), and compared with the preoperative comparison, the levels of tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) interleukin-6 (IL-6) in the two groups were increased, and the indexes of the experimental group were lower than those of the control group (P<0.05). The complication rate in the experimental group was 12% (6/50), which was no significant difference (P>0.05) compared with 14% (7/50) in the control group, and the survival rate and recurrence rate of patients in the experimental group were 90% and 28.00%, respectively, compared with 88.00% and 32.00% in the control group (P>0.05).

Conclusion  Wedge lung resection can achieve good surgical results in elderly patients with stage Ib non-small cell lung cancer, shorten the operation time, reduce intraoperative blood loss, reduce surgical stress response, reduce the level of inflammation, and do not increase postoperative complications, and the long-term prognosis is ideal.

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