Exploring the correlation between chronic obstructive pulmonary disease and gut microbiota based on mendelian randomization and mediation analysis

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Affiliation: 1. School of Public Health, Capital Medical University, Beijing 100069, China 2. School of Biomedical Engineering, Capital Medical University, Beijing 100069, China

Keywords: Chronic obstructive pulmonary disease Single nucleotide polymorphisms Mendelian randomization Mediation analysis

DOI: 10.12173/j.issn.1004-4337.202405005

Reference: Zhou ZJ, Hua L. Exploring the correlation between chronic obstructive pulmonary disease and gut microbiota based on mendelian randomization and mediation analysis[J]. Journal of Mathematical Medicine, 2024, 37(8): 584-591. DOI: 10.12173/j.issn.1004-4337.202405005[Article in Chinese]  Copied

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Abstract

Objective To explore the correlation between gut microbiota and chronic obstructive pulmonary disease (COPD) based on Mendelian randomization.

Methods Gut microbiota was used as exposure factors, COPD as an outcome factor, and single nucleotide polymorphisms (SNPs) as instrumental variables to explore the relationship between gut microbiota and COPD using Mendelian randomization analysis.

Results 13 kinds of COPD-associated bacteria were found, and Lachnospiraceae (P=0.023), Clostridiumsensustricto (P=0.039) and Akkermansia (P=0.047) were the most significant bacteria associated with COPD. Interleukin-4 (IL-4) was the inflammatory factor which was associated with the greatest number of bacteria. By the mediation analysis, it was found that IL-4 mediated the relationship between three bacteria (Clostridiumsensustricto, Enterorhabdus, Ruminococcaceae) and COPD.

Conclusion Gut microbiota has an impact on airway inflammation and lung function in COPD. For example, the population with smoke or asthma may experience a significant decrease in the abundance of Lachnospiraceae, and there is a significant correlation between Ruminococcaceae and cellular inflammatory cytokine levels.

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