Benign prostatic hyperplasia (BPH) is a common male urinary system disease with a complex pathogenesis. The activation of phosphatidylinositide 3-kinases (PI3K)/protein kinase B (AKT) signaling pathway is closely related to the proliferation, apoptosis, migration of prostate cells and inflammatory response. By regulating this signaling pathway, abnormal hyperplasia of prostate tissue can be effectively controlled. Traditional Chinese medicine (TCM), as an important alternative therapy, has the advantages of multiple components, pathways, and targets, as well as the ability to regulate balance within the body. It is widely used in the treatment of BPH in clinical practice. Recent studies have shown that TCM can improve BPH by inhibiting the expression and activation of PI3K/AKT signaling pathway and regulating the expression of related regulatory factors. This review comprehensively analyzed and summarized the role of PI3K/AKT signaling pathway in BPH and its relationship with TCM, providing a pathway for comprehensively understanding the pathological mechanism of BPH and TCM intervention and treatment from the aspects of etiology and pathogenesis, TCM internal treatment, TCM external treatment, etw. It is expected to provide new strategies for the prevention and treatment of BPH.

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