Both diabetes mellitus and atherosclerosis have the clinical characteristics of insidious onset and slow development, which are often mistreated and lead to irreversible adverse outcomes. The pathogenesis of atherosclerosis is complex and diverse, ultimately, the inflammatory response destroys endothelial cell stracture and funktion, resulting in atherosclerosis. Many scholars have found a certain correlation between diabetes and the occurrence of atherosclerosis. atherosclerosis is more likely to occur after diabetes and is closely related to the development of cardiovascular disease. In recent years, there have been more and more studies on the traditional Chinese medicine treatment of diabetes mellitus with atherosclerosis and good results have been obtained, which provides a new basis for the prevention and treatment of cardiovascular diseases from the treatment of diabetes mellitus with atherosclerosis.

1.杨文英. 中国糖尿病的流行特点及变化趋势[J]. 中国科学(生命科学), 2018, 48(8): 812-819. [Yang WY. Epidemiology and trends in diabetes in China[J]. Science in China(Series C), 2018, 48(8): 812-819.] DOI: 10.1360/N052018-00005.

2.Sow D, Diédhiou D, Diallo IM, et al. Morbi infectious mortality of diabetics hospitalized at the medical clinic of Abass Ndao Health Center[J]. Open Journal of Endocrine and Metabolic Diseases, 2018, 8(1): 1-8. DOI: 10.4236/ojemd.2018.81001.

3.洪天配, 母义明, 纪立农, 等. 2型糖尿病合并动脉粥样硬化性心血管疾病患者降糖药物应用专家共识[J]. 中国糖尿病杂志, 2017, 25(6): 481-492. [Hong TP, Mu YM, Ji LN, et al. Chinese expert consensus on anti-diabetic agents in treating patients with type 2 diabetes and atherosclerotic cardiovascular disease[J]. Chinese Journal of Diabetes, 2017, 25(6): 481-492.] DOI: 10.3969/j.issn.1006-6187. 2017.06.001.

4.莫小雄, 莫小庆, 陈杰. 颈动脉粥样硬化病变程度对冠状动脉病变程度及其预后的预测价值研究[J]. 中国处方药, 2020, 18(6): 138-139. [Mo XX, Mo XQ, Chen J. Study on the prediction value of the degree of carotid atherosclerosis to the degree of coronary artery disease and prognosis[J]. Journal of China Prescription Drug, 2020, 18(6): 138-139.] DOI: 10.3969/j.issn.1671-945X.2020.06.078.

5.孔令堃, 李亚玉, 曲青霞, 等. 外周动脉斑块超声评估数据联合常规临床危险因素预测冠状动脉粥样硬化[J]. 临床超声医学杂志, 2020, 22(8): 566-570. [Kong LK, Li YY, Qu QX, et al. Prediction of coronary atherosclerosis by ultrasound evaluation date of peripheral arterial plaque combined with conventional clinical risk factors[J]. Journal of Clinical Ultrasound in Medicine, 2020, 22(8): 566-570.] DOI: 10.3969/j.issn.1008-6978.2020.08.003.

6.程晓艺, 寇秀玲, 黄明刚, 等. 颈动脉斑块与冠状动脉粥样硬化相关性影像学分析[J].心血管病学进展, 2019, 40(6): 960-966. [Cheng XY, Kou XL, Huang MG, et al. Imaging analysis of carotid plaque and coronary artery atherosclerosis[J]. Advances in Cardiovascular Diseases, 2019, 40(6): 960-966.] DOI: 10.16806/j.cnki.issn.1004-3934.2019.06.030.

7.衡先培. 中西医结合防治糖尿病动脉粥样硬化的思路与方法[J]. 中国中西医结合杂志, 2007, 27(8): 679-680. [Heng XP. Thinking and methodology of prevention and treatment of diabetic atherosclerosis with integrative Chinese and western medicine[J]. Chinese Journal of Integrated Traditional and Western Medicine, 2007, 27(8): 679-680.] DOI: 10.3321/j.issn:1003-5370.2007.08.003.

8.Chilelli NC, Cremasco D, Cosma C, et al. Effectiveness of a diet with low advanced glycation end products, in improving glycoxidation and lipid peroxidation: along-term investigation in patients with chronic renal failure [J]. Endocrine, 2016, 54(2): 552-555. DOI: 10.1007/s12020-015-0805-5.

9.杨彩娴, 黄启亚, 钟国权, 等. 新诊断2型糖尿病早期胰岛素强化治疗后三种治疗方案对胰岛β细胞功能及胰岛素抵抗的影响[J]. 中华糖尿病杂志, 2016, 8(10): 613-617. [Yang CX, Huang QY, Zhong GQ, et al. Effect of different treatment on pancreatic β-cell function and insulin resistance after initial intensive insulin therapy in newly diagnosed type 2 diabetes[J]. Chinese Journal of Diabetes, 2016, 8(10): 613-617.] DOI: 10.3760/cma.j.issn.1674-5809.2016.10.009.

10.龙颖琳, 刘仲奇, 刘灿, 等. 波动性高血糖致血管重构作用[J].中国动脉硬化杂志, 2013, 21(8): 763-768. [Long YL, Liu ZQ, Liu C, et al. Vascular remodeling induced by fluctuating hyperglycemia[J]. Chinese Journal of Arteriosclerosis, 2013, 21(8): 763-768.] DOI: CNKI:SUN:KDYZ.0.2013-08-022.

11.李焱. 炎症、胰岛素抵抗是2型糖尿病和动脉粥样硬化的共同基础[J]. 国外医学(内分泌学分册), 2005, 25(3): 150-152. [Li Y. Inflammation and insulin resistance are the common basis of type 2 diabetes mellitus and atherosclerosis[J]. International Journal of Endocrinology and Metabolism, 2005, 25(3):150-152.] DOI: 10.3760/cma.j.issn.1673-4157. 2005.03.003.

12.钟林娜, 张丽锋. 吡格列酮减轻2型糖尿病患者胰岛素抵抗对颈动脉粥样硬化的影响[J]. 临床合理用药杂志, 2017, 10(36): 47-48. [Zhong LN, Zhang LF. Effects of pioglitazone on insulin resistance in patients with type 2 diabetes mellitus on carotid atherosclerosis[J]. Journal of Clinical Rational Drug Use, 2017, 10(36): 47-48.] DOI: 10.15887/j.cnki.13-1389/r.2017.36.023.

13.Rhee EJ, Han K, Ko SH. Increased risk for diabetes development in subjects with large variation in total cholesterol levels in 2,827,950Koreans: a nationwide population-based study[J]. PLoS One, 2017, 12(5): e176615. DOI: 10.1371/journal.pone.0176615.

14.Bernardi S, Marcuzzi A, Piscianz E, et al. The complex interplay between lipids, immune system and interleukins in cardio-metabolic diseases[J]. Int J Mol Sci, 2018, 19(12): E4058. DOI: 10.3390/ijms19124058.

15.Joint committee for guideline revision. 2016 Chinese guidelines for the management of dyslipidemia in adults[J]. J Geriatr Cardiol, 2018, 15(1): 1-29. DOI: 10.11909/j.issn. 1671-5411.2018.01.011.

16.赵月娥, 吴才标, 李育新, 等. 海南省黎族人群颈动脉粥样硬化斑块与血脂水平的相关性研究[J]. 中国医科大学学报, 2020, 49(1): 58-61, 66. [Zhao YE, Wu CB, Li YX, et al. Relationship between carotid atherosclerotic plaque and blood lipid in the Li ethnic group in Hainan province[J]. Journal of China Medical University, 2020, 49(1): 58-61, 66.] DOI: 10.12007/j.issn.0258-4646.2020.01.013.

17.李建军. 血脂异常与动脉粥样硬化关系的现代观念[J].中国循环杂志, 2022, 37(3): 212-214. [Li JJ. Modern concept of the relationship between dyslipidemia and atherosclerosis[J]. Chinese Circulation Journal, 2022, 37(3): 212-214.] DOI: 10.3969/j.issn.1000- 3614.2022.03.002.

18.Cao YX, Zhang HW, Jin JL, et al. Prognostic utility of triglyceride-rich lipoprotein- related markers in patients with coronary artery disease[J]. J Lipid Res, 2020, 61(9): 1254-1261. DOI: 10.1194/jlr.RA120000746.

19.Li AJ, Martinez-Moral MP, Al-Malki AL, et al. Mediation analysis for the relationship between urinary phthalate metabolites and type 2diabetes via oxidative stress in a population in Jeddah, Saudi Arabia[J]. Environ Int, 2019, 126: 153-161. DOI: 10.1016/j.envint.2019.01.082.

20.Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: distinct or continuum?[J]. Indian J Endocrinol Metab, 2016, 20(4): 546-551. DOI: 10.4103/2230-8210.183480.

21.McGarry JD. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes[J]. Diabetes, 2002, 51(1): 7-18. DOI: 10.2337/diabetes.51.1.7.

22.Moura J, Madureira P, Leal EC, et al. Immune aging in diabetes and its implications in wound healing[J]. Clin Immunol, 2019, 200: 43-54. DOI: 10.1016/j.clim. 2019.02.002.

23.齐一侠, 张超, 崔世军, 等. 糖尿病后肢缺血大鼠模型的建立与评估[J]. 中国实验动物学报, 2015, 23(6): 586-590, 596. [Qi YX, Zhang C, Cui SJ, et al. Establishment and evaluation of a diabetic rat model of hindlimb ischemia[J]. Acta Laboratorium Animalis Scientia Sinica, 2015, 23(6): 586-590, 596.] DOI: 10.3969/j.issn. 1005-4847.2015.06.008.

24.Lindholm D, Korhonen L, Eriksson O, et al. Recent insights into the role of unfolded protein response in ER stress in health and disease[J]. Front Cell Dev Biol, 2017, 5: 48. DOI: 10.3389/fcell.2017.00048.

25.Schmitz ML, Shaban MS, Albert BV, et al. The crosstalk of endoplasmic reticulum(er) stress pathways with NF-κB: complex mechanisms relevant for cancer, inflammation and infection[J]. Biomedicines, 2018, 6: 58. DOI: 10.3390/biomedicines6020058.

26.Holman RR, Paul SK, Bethel MA. et al. 10-year follow up of in tensive glucose control in type 2 diabetes[J]. N Engl J Med, 2008, 359(15): 1577-1589. DOI: 10.1056/NEJMoa0806470.

27.Almutairi M, Al Batran R, Ussher JR. Glucagon-like peptide–1 receptor action in the vasculature[J]. Peptides, 2019, 111: 26-32. DOI: 10.1016/j.peptides.2018.09.002.

28.Rizzo M, Nikolic D, Patti AM, et al. GLP-1 receptor agonists and reduction of cardiometabolic risk: potential underlying mechanisms[J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864(9PtB): 2814-2821. DOI: 10.1016/j.bbadis.2018.05.012.

29.吴易航, 张宇辉, 张健. SGLT2i恩格列净对2型糖尿病患者心脏保护作用的研究进展[J].心血管病学进展, 2020, 41(8): 787-789, 829. [Wu YH, Zhang YH, Zhang J. Cardiovascular protection of SGLT2i empagliflozin in patients with type 2 diabetes mellitus[J]. Advances in Cardiovascular Diseases,[J]. Advances in Cardiology, 2020, 41(8): 787-789, 829.] DOI: 10.16806/j.cnki.issn.1004-3934.2020.08.001.

30.Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk[J]. Eur Heart J, 2020, 41(1): 111-188. DOI: 10.1093/eurheartj/ehz455.

31.Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins[J]. Lancet, 2005, 366(9493): 1267-1278. DOI: 10.1016/S0140-6736(05)67394-1.

32.Puri R, Libby P, Nissen SE, et al. Long-term effects of maximally intensive statin therapy on changes in coronary atheroma composition: insights from SATURN[J]. Eur Heart J Cardiovasc Imaging, 2014, 15: 380-388. DOI: 10.1093/ehjci/jet251.

33.陶冬连, 邓珊, 胡越, 等. 血小板外泌体在动脉粥样硬化血栓形成中的作用[J]. 中国实验血液学杂志, 2022, 30(3): 975-978. [Tao DL, Deng S, Hu Y, et al. The role of platelet exosomes in atherogenic thrombosis——review[J]. Journal of Experimental Hematology, 2022, 30(3): 975-978.] DOI: 10.19746/j.cnki.issn1009-2137.2022.03.051.

34.Zhang L, Li T, Miao X, et al. Aspirin suppresses NFκB1 expression and inactivates cAMP signaling pathway to treat atherosclerosis[J]. Biofactors, 2019, 45: 343-354. DOI: 10.1002/biof.1487.

35.谢心, 吴坚, 朱虹, 等. 益气养阴方对2型糖尿病动脉粥样硬化患者血脂及血尿酸代谢的影响[J]. 新中医, 2014, 46(5): 143-145. [Xie X, Wu J, Zhu H, et al. Effects of Yiqi and Yangyin Prescription on blood lipid and uric acid metabolism in patients with type 2 diabetes mellitus[J]. Journal of New Chinese Medicine, 2014, 46(5): 143-145.] DOI: 10.13457/j.cnki.jncm.2014.05.056.

36.谢心, 朱忠强, 竺春玲, 等. 益气养阴法对2型糖尿病动脉粥样硬化患者白介素-6核因子Kappa B表达及中医证候疗效影响的临床研究[J]. 四川中医, 2016, 34(2): 61-63. [Xie X, Zhu ZQ, Zhu CL, et al. Clinical study on the expression of interleukin-6 nuclear factor Kappa B in patients with type 2 diabetes mellitus and the effect of traditional Chinese medicine syndrome[J]. Journal of Sichuan Traditional Chinese Medicine, 2016, 34(2): 61-63.] DOI: CNKI:SUN:SCZY.0.2016-02-028.

37.和殿峰. 滋阴活血法治疗糖尿病合并冠状动脉粥样硬化性心脏病临床分析[J]. 中外医疗, 2013, 32(12): 92-94. [He DF. Clinical analysis of nourishing Yin and promoting blood circulation in the treatment of diabetic patients with coronary atherosclerotic heart disease[J]. China Foreign Medical Treatment, 2013, 32(12): 92-94.] DOI: 10.3969/j.issn.1674-0742.2013.12.056.

38.刘小霞, 李婷, 李怀宇, 等. 参芪瓜蒌薤白半夏汤治疗肝肾阴虚型冠状动脉粥样硬化性心脏病合并糖尿病50例[J]. 环球中医药, 2019, 12(12): 1871-1874. [Liu XX, Li T, Li HY, et al. Treatment of 50 cases of coronary atherosclerotic heart disease complicated with diabetes mellitus by Shenqi Gualou Xiebai Banxia Decoction[J]. Global Traditional Chinese Medicine, 2019, 12(12): 1871-1874.] DOI: 10.3969/j.issn.1674-1749. 2019.12.022.

39.刘忠贵. 参芪瓜蒌薤白半夏汤联合柴胡疏肝散治疗冠心病合并心力衰竭[J].中医学报, 2019, 34(2): 388-390, 403. [Liu ZG. Shenqi Gualou Xiebai Banxia Decoction combined with Chaihu Shugan Powder in the treatment of coronary heart disease complicated with heart failure[J]. China Journal of Chinese Medicine, 2019, 34(2): 388-390, 403.] DOI: 10.16368/j.issn.1674-8999.2019.02.091.

40.周宇, 刘亚丽, 郭志芹. 桃红四物汤加减治疗痰瘀互结型2型糖尿病合并动脉粥样硬化的临证经验[J]. 中国民族民间医药, 2020, 29(3): 93-95. [Zhou Y, Liu YL, Guo ZQ. Clinical experience of Taohong Siwu Decoction in the treatment of phlegm-stasis Huojie type 2 diabetes mellitus complicated with atherosclerosis[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2020, 29(3): 93-95.] DOI: CNKI:SUN:MZMJ.0.2020-03-024.

41.卜艳梅, 赵萍, 柯伟杰. 桃红四物汤治疗痰瘀互结型糖尿病合并颈动脉粥样硬化临床研究[J]. 新中医, 2018, 50(7): 103-105. [Bu YM, Zhao P, Ke WJ. Clinical Study of Taohong Siwu Tang for diabetes of phlegm and blood stasis type with carotid atherosclerosis[J]. Journal of New Chinese Medicine, 2018, 50(7): 103-105.] DOI: 10.13457/j.cnki.jncm.2018.07.029.

42.何柳, 何嘉莉, 谢雯雯. 桃红四物汤对痰瘀互结型糖尿病合并动脉粥状硬化患者心率变异性、血脂及CRP的影响[J]. 中国实验方剂学杂志, 2017, 23(13): 169-173. [He L, He JL, Xie WW. Effect of Taohong Siwutang on heart rate variability, blood lipids and CRP of patients of phlegm and blood stasis type diabetes mellitus with atherosclerosis[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2017, 23(13): 169-173.] DOI: 10.13422/j.cnki.syfjx.2017130169.

43.廖华军. 二陈汤的现代药学研究[J]. 中医药学报, 2012, 40(5): 142-144. [Liao HJ. Modern pharmaceutical research of erchen decoction[J]. Acta Chinese Medicine and Pharmacology, 2012, 40(5): 142-144.] DOI: 10.3969/j.issn.1002-2392.2012.05.054.

44.云冰, 吴英萍. 二术二陈汤加减对2型糖尿病痰浊血瘀证主要心血管高危因素的观察[J]. 中国实验方剂学杂志, 2019, 25(23): 104-109. [Yun B, Wu YP. Effect of modified Erzhu Erchentang on major cardiovascular risk factors caused by type 2 diabetes mellitus with phlegm turbidity and blood stasis syndrome[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(23): 104-109.] DOI: 10.13422/j.cnki.syfjx.20192035.

45.任丽, 王阶, 冯玲, 等. 冠脉易损斑块的中医病机治法探讨[J]. 中华中医药学刊, 2011, 29(2): 279-281. [Ren L, Wang J, Feng L, et al. Investigation on pathogenesis and therapy of traditional Chinese medicine of vulnerable plaque of cvoronary arteries[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 29(2): 279-281.] DOI: 10.13193/j.archtcm.2011.02.57.renl.017.

46.王振强, 吕树泉, 王洪亮, 等. 温阳化气法治疗糖尿病颈动脉粥样硬化斑块的有效性研究[J]. 中医临床研究, 2021, 13(11): 67-70. [Wang ZQ, Lyu SQ, Wang HL, et al. A study on the effectiveness of the Wenyang Huaqi therapy on diabetic carotid atherosclerosis plaque[J]. Clinical Journal of Chinese Medicine, 2021, 13(11): 67-70.] DOI: 10.3969/j.issn.1674-7860. 2021.11.023.

47.王骏. 针灸治疗痰湿质体质颈动脉粥样硬化的效果分析[J]. 中国卫生标准管理, 2021, 12(16): 110-113. [Wang J. Effect of acupuncture and moxibustion on carotid atherosclerosis with phlegm dampness constitution[J].China Health Standard Management, 2021, 12(16): 110-113.] DOI: 10.3969/j.issn.1674-9316.2021.16.036.

48.周莉, 史丹蕾. 神阙穴透刺结合中药治疗肥胖病伴高脂血症脾虚湿阻型的临床研究[J]. 上海医药, 2018, 39(8): 20-23. [Zhou L, Shi DL. Clinical study of Shenque acupoint penetration needling combined with traditional Chinese medicine in the treatment of obesity with hyperlipidemia of spleen deficiency dampness type[J]. Shanghai Medical & Pharmaceutical Journal, 2018, 39(8): 20-23.] DOI: 10.3969/j.issn.1006-1533.2018.08.007.

49.倪振英, 陆霞, 郭永娟, 等. 针刺肾俞五十七穴配合闪罐法治疗肝郁脾虚型肥胖并发高脂血症104例[J].山东中医药大学学报, 2017, 41(4): 352-354. [Ni ZY, Lu X, Guo YJ, et al. Needling fifty-seven Shenshu acupoints combined with flash cupping for treating 104 patients with obesity complicated with hyperlipidemia of liver Qi stagnation and spleen deficiency type[J]. Journal of Shandong University of Traditional Chinese Medicine, 2017, 41(4): 352-354.] DOI: 10.16294/j.cnki.1007-659x.2017.04.017.

50.罗萌萌, 王海泉, 程宽. 艾灸疗法对糖尿病慢性并发症的疗效研究概况[J]. 中医外治杂志, 2018, 27(4): 54-55. [Luo MM, Wang HQ, Cheng K. A survey of the curative effect of moxibustion therapy on chronic complications of diabetes[J]. Journal of External Treatment of Traditional Chinese Medicine, 2018, 27(4): 54-55.] DOI: 10.3969/j.issn.1006-978X.2018.04.029.

51.王桂英, 王耀帅, 高建芸, 等. 不同温度艾灸对高脂血症大鼠血脂及背根神经节瞬时感受器电位香草酸受体1 mRNA表达的影响[J]. 中国中医药信息杂志, 2017, 24(11): 44-47. [Wang GY, Wang YS, Gao JY, et al. Effect of moxibustion at different temperature on mRNA expression of vanillate receptor 1 and transient receptor potential in dorsal root ganglion of hyperlipidemia rats[J]. Chinese Information Journal of Traditional Chinese Medicine, 2017, 24(11): 44-47.] DOI: 10.3969/j.issn.1005-5304.2017.11.011.

52.邹逸凡, 马明珠, 赵钊, 等. 隔药饼灸对高脂血症合并动脉粥样硬化兔肝脏过氧化酶体增殖物激活型受体γ、B类Ⅰ型清道夫受体蛋白及基因表达的影响[J]. 针刺研究, 2018, 43(2): 86-91. [Zou YF, Ma MZ, Zhao Z, et al. Effect of herbal-cake-separated moxibustion on blood lipid levels and expression of hepatic PPARγ and SR-B 1 proteins and genes in hyperlipidemia atherosclerosis rabbits[J]. Acupuncture Research, 2018, 43(2): 86-91.] DOI: 10.13702/j.1000-0607.170729.

53.刘耀萌, 崔莹雪, 哈略, 等. 艾灸及艾烟对动脉粥样硬化模型小鼠血清TNF-α、hs-CRP及vWF的影响[J].中华中医药杂志, 2016, 31(4): 1377-1379. [Liu YM, Cui YX, Ha L, et al. Effects of moxibustion and moxa smoke on TNF-α, hs-CRP, vWF in serum of atherosclerosis mice[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2016, 31(4): 1377-1379.] DOI: CNKI:SUN:BXYY.0.2016-04-071.