Acute gouty arthritis (AGA) is the most common type of gout. Monosodium urate crystals formed by the increase, accumulation and deposition of uric acid are the main causes. Oxidative stress (OS) response has an important effect on AGA. Inflammatory reaction and OS reaction occur at the same time during the attack of AGA, both of which will cause damage to the body. In the treatment of AGA, the drugs used in Western medicine to reduce uric acid, immunosuppressants and indomethacin, as well as the drugs used in traditional Chinese medicine to clear heat, remove dampness, remove arthralgia, relax muscles and activate collaterals, all have certain antioxidant stress effects. In recent years, most of the related studies have focused on inflammation. This paper reviews the mechanism of OS during the attack of AGA and the mechanism of antioxidant stress during the treatment of AGA. to provide reference for clinicians in the treatment of AGA and for the development of new drugs.

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