Objective  To establish a spectrum-effect correlation mathematical model of water-soluble components of Salvia miltiorrhiza and explore the correlation between water-soluble components of Salvia miltiorrhiza and cardiac repair, angiogenesis and vasodilatation.

Methods  The peak areas of high performance liquid chromatography fingerprint for nine water-soluble components of Salvia miltiorrhiza and their medicinal effects on zebrafish angiogenesis, cardiac protection and vasodilation were obtained by database retrieval. The spectrum-effect correlation mathematical model of water-soluble components of Salvia miltiorrhiza was established by stepwise regression method.

Results  Lithospermic acid was the key influencing factor to promote cardiac repair. Rosmarinic acid and salvianolic acid H were the key influencing factors to promote angiogenesis. Salvianolic acid H and salvianolic acid E were the key influencing factors to promote vasodilation.

Conclusion  Among the nine water-soluble components of Salvia miltiorrhiza, lithospermic acid, rosmarinic acid, salvianolic acid H and salvianolic acid E have significant activity against erosclerosis, but their mechanisms require further study. This study can provide reference for the activity screening of the water-soluble components of Salvia miltiorrhiza on cardiac protection, promotion of angiogenesis and vasodilation.

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