Diagnostic value of serum interleukin-17 combined with procalcitonin in the pulmonary bacterial infection combined with decompensation period of cirrhosis

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Author: Dan PANG Xiao-Hu ZHANG Ping ZHAO Cheng-Guo YAN  Xi-Zeng ZHU

Affiliation: Department of Infectious Diseases, Nanyang Central Hospital, Nanyang 473000, Henan Province, China

Keywords: Decompensation period of cirrhosis Interleukin-17 Procalcitonin Pulmonary infection

DOI: 10.12173/j.issn.1004-4337.202301058

Reference: Pang D, Zhang XH, Zhao P, Yan CG, Zhu XZ. Diagnostic value of serum interleukin-17 combined with procalcitonin in the pulmonary bacterial infection combined with decompensation period of cirrhosis[J]. Journal of Mathematical Medicine, 2023, 36(8): 626-631. DOI: 10.12173/j.issn.1004-4337.202301058[Article in Chinese]  Copied

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Abstract

Objective To investigate the clinical value of serum interleukin-17 (IL^-17) combined with procalcitonin in the diagnosis of pulmonary bacterial infection with decompensation period of cirrhosis.

Methods A total of 143 patients with decompensation period of cirrhosis in the department of infectious diseases, Nanyang Central Hospital between January 2022 to June 2022 were enrolled and divided into infection group (n=62) and non-infection group (n=81). The difference of clinical baseline data and serum IL^-17 expression level between the two groups were compared. Logistic regression analysis was used to analyze the influencing factors of pulmonary bacterial infection in patients with decompensation period of cirrhosis. ROC curve was used to analyze the diagnostic value of serum interleukin-17 combined with procalcitonin in the incidence of pulmonary bacterial infection in patients with decompensation period of cirrhosis.

Results Compared with the non-infection group, the levels of WBC (P<0.001), N (P<0.001), hs-CRP (P<0.001), PCT (P<0.001), PT (P<0.001), APTT (P<0.001), INR (P=0.006) significantly increased, while the level of ALB significantly decreased (P<0.001). The serum levels of IL^-17 in the non-infection group and the infection group were (48.18±10.23) ng/mL and (102.33±14.82) ng/mL, respectively. The serum levels of IL^-17 in infection group significantly increased (P<0.001). Multivariate Logistic regression analysis showed that PCT (OR=1.321) and IL^-17 (OR=1.791) were independent risk factors for pulmonary bacterial infection in patients with decompensation period of cirrhosis. The AUC of IL^-17 in the diagnosis of pulmonary bacterial infection in patients with decompensation period of cirrhosis was 0.891, the diagnostic sensitivity and specificity were 87.12% and 89.45%, respectively. The AUC of PCT was 0.862, the diagnostic sensitivity and specificity were 86.12% and 85.67%, respectively. The AUC of IL^-17 combined with PCT was 0.932, the diagnostic sensitivity and specificity were 90.13% and 91.452%, respectively.

Conclusion The serum IL^-17 levels were significantly higher expressed in patients with decompensation period of cirrhosis complicated with pulmonary bacterial infection. The IL^-17 combined with PCT has a good clinical efficacy in the diagnosis of decompensation period of cirrhosis complicated with pulmonary bacterial infection.

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