Objective To systematically evaluate the prevalence of peripheral arterial disease in Chinese hypertensive patients.
Methods Web of Science, Pubmed, Embase, The Cochrane Library, WanFang Data, VIP, CNKI and SinoMed databases were systematically searched for cross-sectional studies from the establishment of the databases to April 18, 2023. Stata 15.0 software was used to summarize the prevalence. Results A total of 13 articles involving 32,190 hypertensive patients were included. The overall prevalence of peripheral arterial disease in Chinese hypertensive patients was 21.00%[95%CI(18.00%, 24.00%), P<0.001]. The results of subgroup analysis showed that the prevalence of peripheral arterial disease was higher in Chinese hypertensive patients with male, northwest region, diabetes, coronary heart disease and stroke.
Conclusion The prevalence of peripheral arterial disease in hypertensive patients in China is high. For patients with hypertension in China, peripheral arterial disease still needs more social attention.
1.Criqui MH, Aboyans V. Epidemiology of peripheral artery disease[J]. Circ Res, 2015, 116(9): 1509-1526. DOI: 10.1161/CIRCRESAHA.116.303849.
2.Campia U, Gerhard-Herman M, Piazza G, et al. Peripheral artery disease: past, present, and future[J]. Am J Med, 2019, 132(10): 1133-1141. DOI: 10.1016/j.amjmed.2019.04.043.
3.Bevan GH, White Solaru KT. Evidence-based medical management of peripheral artery disease[J]. Arterioscler Thromb Vasc Biol, 2020, 40(3): 541-553. DOI: 10.1161/ATVBAHA.119.312142.
4.Shamaki GR, Markson F, Soji-Ayoade D, et al. Peripheral artery disease: a comprehensive updated review[J]. Curr Probl Cardiol, 2022, 47(11): 101082. DOI: 10.1016/j.cpcardiol.2021.101082.
5.Fowkes FG, Rudan D, Rudan I, et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis[J]. Lancet, 2013, 382(9901): 1329-1340. DOI: 10.1016/S0140-6736(13)61249-0.
6.Song P, Rudan D, Zhu Y, et al. Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis[J]. Lancet Glob Health, 2019, 7(8): e1020-e1030. DOI: 10.1016/S2214-109X(19)30255-4.
7.刘琴, 柯大智, 陈庆伟, 等. 老年人下肢动脉粥样硬化与心血管危险因素相关性分析[J]. 中国循环杂志, 2015, 30(11): 1076-1080. [Liu Q, Ke DZ, Chen QW, et al. Relationship between lower extremity atherosclerosis and cardiovascular risk factors in elder people[J]. Chinese Circulation Journal, 2015, 30(11): 1076-1080.] DOI: 10.3969/j.issn.1000-3614.2015.11.011.
8.Liang Y, Yan Z, Sun B, et al. Cardiovascular risk factor profiles for peripheral artery disease and carotid atherosclerosis among Chinese older people: a population-based study[J]. PLoS One, 2014, 9(1): e85927. DOI: 10.1371/journal.pone.0085927.
9.曾宪涛, 刘慧, 陈曦, 等. Meta分析系列之四: 观察性研究的质量评价工具[J]. 中国循证心血管医学杂志, 2012, 4(4): 297-299. [Zeng XT, Liu H, Chen X, et al. Meta-analysis series IV: a quality assessment tool for observational studies[J]. Chinese Journal of Evidence-Based Cardiovascular Medicine, 2012, 4(4): 297-299.] DOI: 10.3969/j.1674-4055.2012.04.004.
10.朱平, 李小鹰, 樊瑾. 老年男性高血压病合并下肢动脉硬化症诊断方法的研究[J]. 军医进修学院学报, 2003, 24(2): 129-131. [Zhu P, Li XY, Fan J. Investigation on the clinical diagnostic method for low extremity atherosclerosis disease in the aged male hypertensive patients[J]. Academic Journal of Chinese PLA Medical School, 2003, 24(2): 129-131.] DOI: 10.3969/j.issn.1005-1139.2003.02.018.
11.Yang X, Sun K, Zhang W, et al. Prevalence of and risk factors for peripheral arterial disease in the patients with hypertension among Han Chinese[J]. J Vasc Surg, 2007, 46(2): 296-302. DOI: 10.1016/j.jvs.2007.03.034.
12.蔡群. 高血压患者踝臂指数的临床研究[J]. 重庆医学, 2009, 38(23): 3009-3010. [Cai Q. Clinical study of the ankle-brachial index in hypertensive patients[J]. Chongqing Medicine, 2009, 38(23): 3009-3010.] DOI: 10.3969/j.issn.1671-8348.2009.23.048.
13.荆文庆, 徐长丽. 踝肱指数评价高血压患者下肢动脉病变的临床意义[J]. 宁夏医学杂志, 2009, 31(5): 406-407. [Jing WQ, Xu CL. The clinical value of ankle brachial index in the evaluation of peripheral artery disease in patients with hypertension[J]. Ningxia Medical Journal, 2009, 31(5): 406-407.] DOI: 10.3969/j.issn.1001-5949.2009.05.010.
14.丁一妹, 王玉, 李燕, 等. 高龄高血压患者外周动脉性疾病患病率及危险因素[J]. 中国医学科学院学报, 2011, 33(2): 162-168. [Ding YM, Wang Y, Li Y, et al. Prevalence and risk factors of peripheral arterial diseases in male Chinese octogenarians and nonagenarians with hypertension[J]. Acta Academiae Medicinae Sinicae, 2011, 33(2): 162-168.] DOI: 10.3881/j.issn.1000-503X.2011.02.013.
15.李燕, 丁一妹, 朱平, 等. 踝肱指数评价老年男性高血压患者下肢动脉病变的临床意义[J]. 山东医药, 2011, 51(4): 8-10. [Li Y, Ding YM, Zhu P, et al. The clinical value of ankle brachial index in the evaluation of peripheral artery disease in patients of aged men with hypertension[J]. Shandong Medical Journal, 2011, 51(4): 8-10.] DOI: 10.3969/j.issn.1002-266X.2011.04.005.
16.张旭, 孙振学, 吕豪. 老年高血压患者踝臂指数异常及其危险因素的研究[J]. 临床荟萃, 2011, 26(11): 969-971. [Zhang X, Sun ZX, Lyu H. Study on abnormal ankle-brachial index and its risk factors in elderly hypertensive patients[J]. Clinical Focus, 2011, 26(11): 969-971.] DOI: CNKI:SUN:LCFC.0.2011-11-019.
17.He M, Qin X, Cui Y, et al. Prevalence of unrecognized lower extremity peripheral arterial disease and the associated factors in Chinese hypertensive adults[J]. Am J Cardiol, 2012, 110(11): 1692-1698. DOI: 10.1016/j.amjcard.2012.07.038.
18.彭小刚, 施胜铭. 高血压合并外周动脉疾病患者动态血压特征分析[J]. 心脑血管病防治, 2014, 14(5): 408-410. [Peng XG, Shi SM. Analysis of ambulatory blood pressure characteristics in patients with hypertension complicated with peripheral arterial disease[J]. Prevention and Treatment of Cardio-Cerebral-Vascular Disease, 2014, 14(5): 408-410.] DOI: 10.3969/j.issn.1009-816x.2014.05.19.
19.崔亚奇. 高血压住院患者下肢外周动脉病及其危险因素分析[J]. 山西医药杂志, 2016, 45(12): 1453-1455. [Cui YQ. Analysis of lower extremity peripheral arterial disease and its risk factors in hospitalized patients with hypertension[J]. Shanxi Medical Journal, 2016, 45(12): 1453-1455.] DOI: 10.3969/j.issn.0253-9926.2016.12.038.
20.王贵鹏, 赵亮, 王海旭. 老年高血压患者下肢动脉病变与踝臂指数的相关性[J]. 中国老年学杂志, 2016, 36(12): 2884-2885. [Wang GP, Zhao L, Wang HX. Correlation between lower extremity arterial disease and ankle brachial index in elderly hypertensive patients[J]. Chinese Journal of Gerontology, 2016, 36(12): 2884-2885.] DOI: 10.3969/j.issn.1005-9202.2016.12.026.
21.Liu H, Zha X, Ding C, et al. AST/ALT ratio and peripheral artery disease in a Chinese hypertensive population: a cross-sectional study[J]. Angiology, 2021, 72(10): 916-922. DOI: 10.1177/00033197211004410.
22.周伟, 余超, 祝玲娟, 等. 高血压患者血尿酸、肾小球滤过率与外周动脉疾病的相关性[J]. 中华高血压杂志, 2022, 30(9): 875-880. [Zhou W, Yu C, Zhu LJ, et al. Correlation between serum uric acid, glomerular filtration rate and peripheral arterial disease in patients with hypertension[J]. Chinese Journal of Hypertension, 2022, 30(9): 875-880.] DOI: 10.16439/j.issn.1673-7245.2022.09.015.
23.赵倩南, 关绍晨, 王淳秀, 等. 高血压与外周动脉疾病患病关系的横断面研究[J]. 中华高血压杂志, 2020, 28(2): 149-154. [Zhao QN, Guan SC, Wang CX, et al. A cross-sectional analysis on the relationship between hypertension and peripheral artery disease[J]. Chinese Journal of Hypertension, 2020, 28(2): 149-154.] DOI: CNKI:SUN:ZGGZ.0.2020-02-019.
24.Shou Z, Zhao Y, Zhang Y, et al. Risk factors for peripheral arterial disease in elderly patients with type-2 diabetes mellitus: a clinical study[J]. Pak J Med Sci, 2020, 36(6): 1344-1348. DOI: 10.12669/pjms.36.6.2906.
25.Sampson UK, Fowkes FG, McDermott MM, et al. Global and regional burden of death and disability from peripheral artery disease: 21 world regions, 1990 to 2010[J]. Glob Heart, 2014, 9(1): 145-158.e21. DOI: 10.1016/j.gheart.2013.12.008.
26.Pabon M, Cheng S, Altin SE, et al. Sex differences in peripheral artery disease[J]. Circ Res, 2022, 130(4): 496-511. DOI: 10.1161/CIRCRESAHA.121.320702.
27.Shi Y, Yu C, Hu L, et al. Visceral adiposity index and sex differences in relation to peripheral artery disease in normal-weight adults with hypertension[J]. Biol Sex Differ, 2022, 13(1): 22. DOI: 10.1186/s13293-022-00432-4.
28.Boese AC, Kim SC, Yin KJ, et al. Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease[J]. Am J Physiol Heart Circ Physiol, 2017, 313(3): H524-H545. DOI: 10.1152/ajpheart.00217.2016.
29.高璐, 秦明照. 老年糖尿病患者代谢综合征与外周动脉疾病的相关性分析[J]. 中华老年心脑血管病杂志, 2020, 22(9): 917-919. [Gao L, Qin MZ. Correlation between metabolic syndrome and peripheral arterial disease in elderly T2DM patients[J]. Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 2020, 22(9): 917-919.] DOI: 10.3969/j.issn.1009-0126.2020.09.006.
30.Gherasie FA, Popescu MR, Bartos D. Acute coronary syndrome: disparities of pathophysiology and mortality with and without peripheral artery disease[J]. J Pers Med, 2023, 13(6): 944. DOI: 10.3390/jpm13060944.